PDBsum entry 4qla

Hydrolase

PDB id: 4qla

Contents

Protein chains

424 a.a.

380 a.a.

Ligands

1PE ×2

Waters ×159

PDB id:

4qla

Name:

Hydrolase

Title:

Crystal structure of juvenile hormone epoxide hydrolase from the silkworm bombyx mori

Structure:

Juvenile hormone epoxide hydrolase. Chain: a, b. Fragment: unp residues 23-461. Synonym: bommo-jheh. Engineered: yes. Mutation: yes

Source:

Bombyx mori. Silk moth, silkworm. Organism_taxid: 7091. Expressed in: escherichia coli. Expression_system_taxid: 562.

Resolution:

2.30Å R-factor: 0.206 R-free: 0.251

Authors:

K.Zhou,N.Jia,C.Hu,Y.L.Jiang,J.P.Yang,Y.Chen,S.Li,C.Z.Zhou

Key ref:

K.Zhou et al. (2014). Crystal structure of juvenile hormone epoxide hydrolase from the silkworm Bombyx mori. Proteins, 82, 3224-3229. PubMed id: 25143157 DOI: 10.1002/prot.24676

Date:

11-Jun-14 Release date: 03-Sep-14

Protein chain

Q6U6J0  (HYEP_BOMMO) -  Juvenile hormone epoxide hydrolase from Bombyx mori

Seq: 461 a.a.

Struc: 424 a.a.*

Protein chain

Q6U6J0  (HYEP_BOMMO) -  Juvenile hormone epoxide hydrolase from Bombyx mori

Seq: 461 a.a.

Struc: 380 a.a.*

* PDB and UniProt seqs differ at 12 residue positions (black crosses)

Enzyme reactions

• Enzyme class: Chains A, B: E.C.3.3.2.9 - microsomal epoxide hydrolase.
• Reaction:
  1. cis-stilbene oxide + H2O = (1R,2R)-hydrobenzoin
  2. 1-(4-methoxyphenyl)-N-methyl-N-[(3-methyloxetan-3- yl)methyl]methanamine + H2O = 2-{[(4-methoxybenzyl)(methyl)amino]methyl}- 2-methylpropane-1,3-diol

Molecule diagrams generated from .mol files obtained from the KEGG ftp site

Key reference

DOI no: 10.1002/prot.24676

Proteins 82:3224-3229 (2014)

PubMed id: 25143157

Crystal structure of juvenile hormone epoxide hydrolase from the silkworm Bombyx mori.

K.Zhou, N.Jia, C.Hu, Y.L.Jiang, J.P.Yang, Y.Chen, S.Li, W.F.Li, C.Z.Zhou.

ABSTRACT

No abstract given.