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PDBsum entry 4pnp

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protein ligands links
Phosphorylase PDB id
4pnp
Jmol
Contents
Protein chain
284 a.a. *
Ligands
PO4
Waters ×65
* Residue conservation analysis
PDB id:
4pnp
Name: Phosphorylase
Title: The high resolution crystal structure of bovine spleen purin nucleoside phosphorylase in complex forms with phosphate an deazainosine
Structure: Purine nucleoside phosphorylase. Chain: a. Synonym: pnp. Ec: 2.4.2.1
Source: Bos taurus. Cattle. Organism_taxid: 9913. Organ: spleen
Biol. unit: Trimer (from PDB file)
Resolution:
1.80Å     R-factor:   0.222     R-free:   0.248
Authors: M.J.Pugmire,C.Mao,S.E.Ealick
Key ref: M.J.Pugmire et al. The high resolution crystal structure of bovine spleen purine nucleoside phosphorylase in complex forms with phosphate and 9-Deazainosine. To be published, .
Date:
30-Mar-98     Release date:   30-Mar-99    
PROCHECK
Go to PROCHECK summary
 Headers
 References

Protein chain
Pfam   ArchSchema ?
P55859  (PNPH_BOVIN) -  Purine nucleoside phosphorylase
Seq:
Struc:
289 a.a.
284 a.a.*
Key:    PfamA domain  Secondary structure  CATH domain
* PDB and UniProt seqs differ at 1 residue position (black cross)

 Enzyme reactions 
   Enzyme class: E.C.2.4.2.1  - Purine-nucleoside phosphorylase.
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]
      Reaction:
1. Purine nucleoside + phosphate = purine + alpha-D-ribose 1-phosphate
2. Purine deoxynucleoside + phosphate = purine + 2'-deoxy-alpha-D-ribose 1-phosphate
Purine nucleoside
+
phosphate
Bound ligand (Het Group name = PO4)
corresponds exactly
= purine
+ alpha-D-ribose 1-phosphate
Purine deoxynucleoside
+ phosphate
= purine
+ 2'-deoxy-alpha-D-ribose 1-phosphate
Molecule diagrams generated from .mol files obtained from the KEGG ftp site
 Gene Ontology (GO) functional annotation 
  GO annot!
  Cellular component     cytoplasm   2 terms 
  Biological process     nucleobase-containing compound metabolic process   2 terms 
  Biochemical function     catalytic activity     5 terms