PDBsum entry 4ll3

Hydrolase/hydrolase inhibitor

PDB id: 4ll3

Contents

Protein chains

99 a.a.

Ligands

017-017

Waters ×141

PDB id:

4ll3

Name:

Hydrolase/hydrolase inhibitor

Title:

Structure of wild-type HIV protease in complex with darunavir

Structure:

Protease. Chain: a, b. Fragment: unp residues 7-105. Engineered: yes

Source:

Human immunodeficiency virus 1. Organism_taxid: 11676

Resolution:

1.95Å R-factor: 0.185 R-free: 0.230

Authors:

K.Grantz Saskova,P.Rezacova,J.Brynda,M.Kozisek,J.Konvalinka

Key ref:

M.Kožíšek et al. (2014). Thermodynamic and structural analysis of HIV protease resistance to darunavir - analysis of heavily mutated patient-derived HIV-1 proteases. Febs J, 281, 1834-1847. PubMed id: 24785545 DOI: 10.1111/febs.12743

Date:

09-Jul-13 Release date: 16-Apr-14

Supersedes:

3qoz

Protein chains

Q9WFL7  (Q9WFL7_9HIV1) -  Pol polyprotein (Fragment) from Human immunodeficiency virus 1

Seq: 347 a.a.

Struc: 99 a.a.

Enzyme reactions

• Enzyme class: E.C.?

DOI no: 10.1111/febs.12743

Febs J 281:1834-1847 (2014)

PubMed id: 24785545

Thermodynamic and structural analysis of HIV protease resistance to darunavir - analysis of heavily mutated patient-derived HIV-1 proteases.

M.Kožíšek, M.Lepšík, K.Grantz Šašková, J.Brynda, J.Konvalinka, P.Rezáčová.

ABSTRACT

No abstract given.