PDBsum entry 4jni

Hydrolase/hydrolase inhibitor

PDB id: 4jni

Contents

Protein chain

246 a.a.

Ligands

SO4

PZH

PGE ×2

Waters ×193

Superseded by:

5yc6

PDB id:

4jni

Name:

Hydrolase/hydrolase inhibitor

Title:

Crystal structure of upa in complex with its inhibitor 4- bromobenzylamine at ph 4.6

Structure:

Urokinase-type plasminogen activator. Chain: u. Fragment: catalytic domain. Synonym: u-plasminogen activator, upa. Engineered: yes. Mutation: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: plau. Expressed in: saccharomyces cerevisiae. Expression_system_taxid: 4932.

Resolution:

1.17Å R-factor: 0.255 R-free: 0.276

Authors:

X.Zhang,L.Jiang,B.Zhao,C.Yuan,M.Huang

Key ref:

X.Zhang et al. Halogen bonds in the design of serine protease inhibi. To be published, .

Date:

15-Mar-13 Release date: 19-Mar-14

Protein chain

P00749  (UROK_HUMAN) -  Urokinase-type plasminogen activator from Homo sapiens

Seq: 431 a.a.

Struc: 246 a.a.*

* PDB and UniProt seqs differ at 2 residue positions (black crosses)

Enzyme reactions

• Enzyme class: E.C.3.4.21.73 - u-plasminogen activator.
• Reaction: Specific cleavage of Arg-|-Val bond in plasminogen to form plasmin.