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PDBsum entry 4hje

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protein dna_rna metals Protein-protein interface(s) links
Transcription/DNA PDB id
4hje
Jmol
Contents
Protein chains
200 a.a.
DNA/RNA
Metals
_ZN ×4
Waters ×832
PDB id:
4hje
Name: Transcription/DNA
Title: Crystal structure of p53 core domain in complex with DNA
Structure: Cellular tumor antigen p53. Chain: a, b, c, d. Fragment: unp residues 92-291. Synonym: antigen ny-co-13, phosphoprotein p53, tumor suppre engineered: yes. DNA (5'- d( Tp Cp Ap Cp Ap Ap Gp Tp Tp Ap Gp Ap Gp Ap Cp Ap Ap Gp Cp 3'). Chain: e.
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: tp53, p53. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Other_details: this sequence occurs naturally in humans. Other_details: this sequence occurs naturally in humans
Resolution:
1.91Å     R-factor:   0.189     R-free:   0.228
Authors: Y.Chen,L.Chen
Key ref: Y.Chen et al. (2013). Structure of p53 binding to the BAX response element reveals DNA unwinding and compression to accommodate base-pair insertion. Nucleic Acids Res, 41, 8368-8376. PubMed id: 23836939 DOI: 10.1093/nar/gkt584
Date:
12-Oct-12     Release date:   17-Jul-13    
PROCHECK
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 Headers
 References

Protein chains
Pfam   ArchSchema ?
P04637  (P53_HUMAN) -  Cellular tumor antigen p53
Seq:
Struc:
393 a.a.
200 a.a.
Key:    PfamA domain  Secondary structure  CATH domain

 Gene Ontology (GO) functional annotation 
  GO annot!
  Cellular component     nucleus   1 term 
  Biological process     apoptotic process   2 terms 
  Biochemical function     transcription regulatory region DNA binding     3 terms  

 

 
DOI no: 10.1093/nar/gkt584 Nucleic Acids Res 41:8368-8376 (2013)
PubMed id: 23836939  
 
 
Structure of p53 binding to the BAX response element reveals DNA unwinding and compression to accommodate base-pair insertion.
Y.Chen, X.Zhang, A.C.Dantas Machado, Y.Ding, Z.Chen, P.Z.Qin, R.Rohs, L.Chen.
 
  ABSTRACT  
 
No abstract given.