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PDBsum entry 4g3y

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protein Protein-protein interface(s) links
Immune system PDB id
4g3y
Jmol
Contents
Protein chains
214 a.a.
220 a.a.
148 a.a.
Waters ×134
PDB id:
4g3y
Name: Immune system
Title: Crystal structure of tnf-alpha in complex with infliximab fa
Structure: Infliximab fab l. Chain: l. Engineered: yes. Infliximab fab h. Chain: h. Engineered: yes. Tumor necrosis factor. Chain: c. Fragment: tumor necrosis factor, soluble form.
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: tnfa. Expression_system_taxid: 562
Resolution:
2.60Å     R-factor:   0.191     R-free:   0.235
Authors: S.Y.Liang,J.X.Dai,Y.J.Guo,Z.Y.Lou
Key ref: S.Liang et al. (2013). Structural basis for treating tumor necrosis factor α (TNFα)-associated diseases with the therapeutic antibody infliximab. J Biol Chem, 288, 13799-13807. PubMed id: 23504311 DOI: 10.1074/jbc.M112.433961
Date:
15-Jul-12     Release date:   27-Mar-13    
PROCHECK
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 Headers
 References

Protein chain
No UniProt id for this chain
Struc: 214 a.a.
Protein chain
No UniProt id for this chain
Struc: 220 a.a.
Protein chain
Pfam   ArchSchema ?
P01375  (TNFA_HUMAN) -  Tumor necrosis factor
Seq:
Struc:
233 a.a.
148 a.a.
Key:    PfamA domain  Secondary structure  CATH domain

 Gene Ontology (GO) functional annotation 
  GO annot!
  Cellular component     membrane   1 term 
  Biological process     immune response   1 term 
  Biochemical function     tumor necrosis factor receptor binding     1 term  

 

 
DOI no: 10.1074/jbc.M112.433961 J Biol Chem 288:13799-13807 (2013)
PubMed id: 23504311  
 
 
Structural basis for treating tumor necrosis factor α (TNFα)-associated diseases with the therapeutic antibody infliximab.
S.Liang, J.Dai, S.Hou, L.Su, D.Zhang, H.Guo, S.Hu, H.Wang, Z.Rao, Y.Guo, Z.Lou.
 
  ABSTRACT  
 
No abstract given.