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PDBsum entry 4ept

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protein ligands metals links
Hydrolase PDB id
4ept
Jmol
Contents
Protein chain
166 a.a.
Ligands
GDP
0QW
Metals
_MG
Waters ×116
PDB id:
4ept
Name: Hydrolase
Title: Discovery of small molecules that bind to k-ras and inhibit mediated activation
Structure: Gtpase kras. Chain: a. Fragment: catalytic. Synonym: k-ras 2, ki-ras, c-k-ras, c-ki-ras, gtpase kras, n terminally processed. Engineered: yes. Mutation: yes
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: kras, kras2, rask2. Expressed in: escherichia coli. Expression_system_taxid: 562
Resolution:
2.00Å     R-factor:   0.232     R-free:   0.274
Authors: Q.Sun,J.P.Burke,J.Phan,M.C.Burns,E.T.Olejniczak,A.G.Waterson O.W.Rossanese,S.W.Fesik
Key ref: Q.Sun et al. (2012). Discovery of small molecules that bind to K-Ras and inhibit Sos-mediated activation. Angew Chem Int Ed Engl, 51, 6140-6143. PubMed id: 22566140
Date:
17-Apr-12     Release date:   23-May-12    
PROCHECK
Go to PROCHECK summary
 Headers
 References

Protein chain
Pfam   ArchSchema ?
P01116  (RASK_HUMAN) -  GTPase KRas
Seq:
Struc:
189 a.a.
166 a.a.*
Key:    PfamA domain  Secondary structure  CATH domain
* PDB and UniProt seqs differ at 5 residue positions (black crosses)

 Gene Ontology (GO) functional annotation 
  GO annot!
  Cellular component     membrane   1 term 
  Biological process     signal transduction   3 terms 
  Biochemical function     GTP binding     1 term  

 

 
Angew Chem Int Ed Engl 51:6140-6143 (2012)
PubMed id: 22566140  
 
 
Discovery of small molecules that bind to K-Ras and inhibit Sos-mediated activation.
Q.Sun, J.P.Burke, J.Phan, M.C.Burns, E.T.Olejniczak, A.G.Waterson, T.Lee, O.W.Rossanese, S.W.Fesik.
 
  ABSTRACT  
 
No abstract given.