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PDBsum entry 4dx2

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protein ligands Protein-protein interface(s) links
Transport protein PDB id
4dx2
Jmol
Contents
Protein chain
247 a.a.
Ligands
BGC
ATP
GOL
Waters ×72
PDB id:
4dx2
Name: Transport protein
Title: Crystal structure of the human trpv4 ankyrin repeat domain
Structure: Transient receptor potential cation channel subfa member 4. Chain: a, b. Fragment: n-terminal domain (unp residues 149-397). Synonym: trpv4, osm-9-like trp channel 4, otrpc4, transient potential protein 12, trp12, vanilloid receptor-like channe vanilloid receptor-like protein 2, vrl-2, vanilloid recepto osmotically-activated channel, vr-oac. Engineered: yes
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: trpv4, vrl2, vroac. Expressed in: escherichia coli. Expression_system_taxid: 562.
Resolution:
2.95Å     R-factor:   0.179     R-free:   0.220
Authors: H.Inada,R.Gaudet
Key ref: H.Inada et al. (2012). Structural and biochemical consequences of disease-causing mutations in the ankyrin repeat domain of the human TRPV4 channel. Biochemistry, 51, 6195-6206. PubMed id: 22702953
Date:
27-Feb-12     Release date:   18-Jul-12    
PROCHECK
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 Headers
 References

Protein chains
Pfam   ArchSchema ?
Q9HBA0  (TRPV4_HUMAN) -  Transient receptor potential cation channel subfamily V member 4
Seq:
Struc:
 
Seq:
Struc:
871 a.a.
247 a.a.*
Key:    PfamA domain  Secondary structure  CATH domain
* PDB and UniProt seqs differ at 1 residue position (black cross)

 Gene Ontology (GO) functional annotation 
  GO annot!
  Cellular component     integral to membrane   1 term 
  Biological process     ion transport   1 term 
  Biochemical function     ion channel activity     1 term  

 

 
Biochemistry 51:6195-6206 (2012)
PubMed id: 22702953  
 
 
Structural and biochemical consequences of disease-causing mutations in the ankyrin repeat domain of the human TRPV4 channel.
H.Inada, E.Procko, M.Sotomayor, R.Gaudet.
 
  ABSTRACT  
 
No abstract given.