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PDBsum entry 4dj9

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protein Protein-protein interface(s) links
Cell adhesion PDB id
4dj9
Jmol
Contents
Protein chains
243 a.a.
22 a.a.
Waters ×62
PDB id:
4dj9
Name: Cell adhesion
Title: Human vinculin head domain vh1 (residues 1-258) in complex w talin vinculin binding site 50 (vbs50, residues 2078-2099)
Structure: Vinculin. Chain: a. Fragment: unp residues 1-258. Synonym: metavinculin. Engineered: yes. Talin-1. Chain: b. Fragment: unp residues 2075-2103. Engineered: yes
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: vcl. Gene: tln1, kiaa1027, tln
Resolution:
2.25Å     R-factor:   0.209     R-free:   0.247
Authors: S.D.Yogesha,E.S.Rangarajan,C.Vonrhein,G.Bricogne,T.Izard
Key ref: S.D.Yogesha et al. (2012). Crystal structure of vinculin in complex with vinculin binding site 50 (VBS50), the integrin binding site 2 (IBS2) of talin. Protein Sci, 21, 583-588. PubMed id: 22334306 DOI: 10.1002/pro.2041
Date:
01-Feb-12     Release date:   29-Feb-12    
PROCHECK
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 Headers
 References

Protein chain
Pfam   ArchSchema ?
P18206  (VINC_HUMAN) -  Vinculin
Seq:
Struc:
 
Seq:
Struc:
 
Seq:
Struc:
1134 a.a.
243 a.a.
Protein chain
Pfam   ArchSchema ?
Q9Y490  (TLN1_HUMAN) -  Talin-1
Seq:
Struc:
 
Seq:
Struc:
 
Seq:
Struc:
 
Seq:
Struc:
 
Seq:
Struc:
 
Seq:
Struc:
2541 a.a.
22 a.a.
Key:    PfamA domain  PfamB domain  Secondary structure  CATH domain

 Gene Ontology (GO) functional annotation 
  GO annot!
  Cellular component     actin cytoskeleton   1 term 
  Biological process     cell adhesion   2 terms 
  Biochemical function     structural molecule activity     2 terms  

 

 
DOI no: 10.1002/pro.2041 Protein Sci 21:583-588 (2012)
PubMed id: 22334306  
 
 
Crystal structure of vinculin in complex with vinculin binding site 50 (VBS50), the integrin binding site 2 (IBS2) of talin.
S.D.Yogesha, E.S.Rangarajan, C.Vonrhein, G.Bricogne, T.Izard.
 
  ABSTRACT  
 
No abstract given.