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PDBsum entry 4c5x

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dna_rna metals links
DNA PDB id
4c5x
Jmol
Contents
DNA/RNA
Metals
_MG
Waters ×136
PDB id:
4c5x
Name: DNA
Title: Ultra high resolution dickerson-drew dodecamer b-DNA with 5-hydroxymethyl-cytosine modification
Structure: 5'-d(cp Gp Cp Gp Ap Ap Tp Tp 5Hcp Gp Cp Gp)-3'. Chain: a, b. Fragment: dickerson-drew sequence dodecamer
Source: Synthetic: yes. Synthetic construct. Organism_taxid: 32630
Resolution:
1.30Å     R-factor:   0.145     R-free:   0.173
Authors: M.Mcdonough,A.H.El-Sagheer,T.Brown,C.J.Schofield
Key ref: L.Lercher et al. (2014). Structural insights into how 5-hydroxymethylation influences transcription factor binding. Chem Commun (Camb), 50, 1794-1796. PubMed id: 24287551 DOI: 10.1039/c3cc48151d
Date:
16-Sep-13     Release date:   02-Oct-13    
 Headers
 References

 

 
DOI no: 10.1039/c3cc48151d Chem Commun (Camb) 50:1794-1796 (2014)
PubMed id: 24287551  
 
 
Structural insights into how 5-hydroxymethylation influences transcription factor binding.
L.Lercher, M.A.McDonough, A.H.El-Sagheer, A.Thalhammer, S.Kriaucionis, T.Brown, C.J.Schofield.
 
  ABSTRACT  
 
Transcription factor binding and high resolution crystallographic studies (1.3 Å) of Dickerson-Drew duplexes with cytosine, methylcytosine and hydroxymethylcytosine bases provide evidence that C-5 cytosine modifications could regulate transcription by context dependent effects on DNA transcription factor interactions.