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PDBsum entry 4bqv
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PDB id:
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Hydrolase
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Title:
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Mouse cathepsin s with covalent ligand
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Structure:
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Cathepsin s. Chain: a, b, c, d, e, f, g, h. Fragment: residues 116-340. Engineered: yes
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Source:
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Mus musculus. House mouse. Organism_taxid: 10090. Expressed in: escherichia coli. Expression_system_taxid: 562
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Resolution:
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1.70Å
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R-factor:
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0.204
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R-free:
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0.240
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Authors:
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D.W.Banner,J.Benz,B.Gsell,M.Stihle,A.Ruf,W.Haap
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Key ref:
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W.Haap
and
d.w.banner
Cathepsin s nitrile inhibitors.
To be published,
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Date:
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03-Jun-13
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Release date:
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18-Jun-14
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PROCHECK
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Headers
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References
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O70370
(CATS_MOUSE) -
Cathepsin S from Mus musculus
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Seq:
Struc:
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340 a.a.
219 a.a.*
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Key: |
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PfamA domain |
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Secondary structure |
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CATH domain |
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*
PDB and UniProt seqs differ
at 1 residue position (black
cross)
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Enzyme class:
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E.C.3.4.22.27
- cathepsin S.
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Reaction:
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Similar to cathepsin L, but with much less activity on Z-Phe-Arg-|-NHMec, and more activity on the Z-Val-Val-Arg-|-Xaa compound.
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Links
