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PDBsum entry 4ago

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protein ligands metals Protein-protein interface(s) links
Cell cycle PDB id
4ago
Jmol
Contents
Protein chains
196 a.a.
Ligands
P74 ×2
Metals
_ZN ×2
Waters ×554
PDB id:
4ago
Name: Cell cycle
Title: Structure of the p53 core domain mutant y220c bound to the stabilizing small molecule phikan5174
Structure: Cellular tumor antigen p53. Chain: a, b. Fragment: DNA-binding domain, residues 94-312. Synonym: antigen ny-co-13, phosphoprotein p53, tumor suppre p53, p53. Engineered: yes. Mutation: yes
Source: Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 562
Resolution:
1.45Å     R-factor:   0.195     R-free:   0.216
Authors: A.C.Joerger,R.Wilcken,A.R.Fersht,F.M.Boeckler
Key ref: R.Wilcken et al. (2012). Halogen-enriched fragment libraries as leads for drug rescue of mutant p53. J Am Chem Soc, 134, 6810-6818. PubMed id: 22439615 DOI: 10.1021/ja301056a
Date:
30-Jan-12     Release date:   21-Mar-12    
PROCHECK
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 Headers
 References

Protein chains
Pfam   ArchSchema ?
P04637  (P53_HUMAN) -  Cellular tumor antigen p53
Seq:
Struc:
393 a.a.
196 a.a.*
Key:    PfamA domain  Secondary structure  CATH domain
* PDB and UniProt seqs differ at 5 residue positions (black crosses)

 Gene Ontology (GO) functional annotation 
  GO annot!
  Cellular component     nucleus   1 term 
  Biological process     apoptotic process   2 terms 
  Biochemical function     transcription regulatory region DNA binding     3 terms  

 

 
DOI no: 10.1021/ja301056a J Am Chem Soc 134:6810-6818 (2012)
PubMed id: 22439615  
 
 
Halogen-enriched fragment libraries as leads for drug rescue of mutant p53.
R.Wilcken, X.Liu, M.O.Zimmermann, T.J.Rutherford, A.R.Fersht, A.C.Joerger, F.M.Boeckler.
 
  ABSTRACT  
 
No abstract given.