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PDBsum entry 4a5t

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protein ligands metals links
Hydrolase PDB id
4a5t
Jmol
Contents
Protein chain
767 a.a.
Ligands
SIA-GAL-NGA
Metals
_CL ×2
PDB id:
4a5t
Name: Hydrolase
Title: Structural basis for the conformational modulation
Structure: Plasminogen. Chain: s. Synonym: plasmin heavy chain a, activation peptide, angiost plasmin heavy chain a\,short form, plasmin light chain b. Ec: 3.4.21.7
Source: Homo sapiens. Human. Organism_taxid: 9606
Resolution:
3.49Å     R-factor:   0.210     R-free:   0.250
Authors: Y.Xue,C.Bodin,K.Olsson
Key ref: Y.Xue et al. (2012). Crystal structure of the native plasminogen reveals an activation-resistant compact conformation. J Thromb Haemost, 10, 1385-1396. PubMed id: 22540246
Date:
28-Oct-11     Release date:   23-May-12    
PROCHECK
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 Headers
 References

Protein chain
Pfam   ArchSchema ?
P00747  (PLMN_HUMAN) -  Plasminogen
Seq:
Struc:
 
Seq:
Struc:
810 a.a.
767 a.a.
Key:    PfamA domain  Secondary structure  CATH domain

 Enzyme reactions 
   Enzyme class: E.C.3.4.21.7  - Plasmin.
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]
      Reaction: Preferential cleavage: Lys-|-Xaa > Arg-|-Xaa; higher selectivity than trypsin. Converts fibrin into soluble products.
 Gene Ontology (GO) functional annotation 
  GO annot!
  Cellular component     extracellular region   10 terms 
  Biological process     mononuclear cell migration   23 terms 
  Biochemical function     catalytic activity     10 terms  

 

 
J Thromb Haemost 10:1385-1396 (2012)
PubMed id: 22540246  
 
 
Crystal structure of the native plasminogen reveals an activation-resistant compact conformation.
Y.Xue, C.Bodin, K.Olsson.
 
  ABSTRACT  
 
No abstract given.