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PDBsum entry 3zys

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protein Protein-protein interface(s) links
Hydrolase/gtp-binding protein PDB id
3zys

 

 

 

 

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Contents
Protein chains
330 a.a.
211 a.a.
113 a.a.
219 a.a.
PDB id:
3zys
Name: Hydrolase/gtp-binding protein
Title: Human dynamin 1 deltaprd polymer stabilized with gmppcp
Structure: Dynamin-1. Chain: a, d. Fragment: g domain, residues 1-320, gtpase effector domain, residues 726-750. Engineered: yes. Other_details: eight amino acid polypeptide linker between g domain and gtpase effector domain, residues 321-328. Interferon-induced gtp-binding protein mx1. Chain: b, e.
Source: Homo sapiens. Human. Organism_taxid: 9606. Variant: isoform 1. Expressed in: escherichia coli. Expression_system_taxid: 469008. Expression_system_variant: rosetta. Expression_system_taxid: 562.
Authors: J.S.Chappie,J.A.Mears,S.Fang,M.Leonard,S.L.Schmid,R.A.Milligan, J.E.Hinshaw,F.Dyda
Key ref: J.S.Chappie et al. (2011). A pseudoatomic model of the dynamin polymer identifies a hydrolysis-dependent powerstroke. Cell, 147, 209-222. PubMed id: 21962517
Date:
24-Aug-11     Release date:   12-Oct-11    
PROCHECK
Go to PROCHECK summary
 Headers
 References

Protein chains
Pfam   ArchSchema ?
Q05193  (DYN1_HUMAN) -  Dynamin-1 from Homo sapiens
Seq:
Struc:
 
Seq:
Struc:
864 a.a.
330 a.a.*
Protein chain
Pfam   ArchSchema ?
P20591  (MX1_HUMAN) -  Interferon-induced GTP-binding protein Mx1 from Homo sapiens
Seq:
Struc:
 
Seq:
Struc:
662 a.a.
211 a.a.
Protein chains
Pfam   ArchSchema ?
Q05193  (DYN1_HUMAN) -  Dynamin-1 from Homo sapiens
Seq:
Struc:
 
Seq:
Struc:
864 a.a.
113 a.a.
Protein chain
Pfam   ArchSchema ?
P20591  (MX1_HUMAN) -  Interferon-induced GTP-binding protein Mx1 from Homo sapiens
Seq:
Struc:
 
Seq:
Struc:
662 a.a.
219 a.a.
Key:    PfamA domain  Secondary structure
* PDB and UniProt seqs differ at 23 residue positions (black crosses)

 Enzyme reactions 
   Enzyme class 2: Chains A, C, D, F: E.C.3.6.5.5  - dynamin GTPase.
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]
      Reaction: GTP + H2O = GDP + phosphate + H+
GTP
+ H2O
= GDP
+ phosphate
+ H(+)
   Enzyme class 3: Chains B, E: E.C.?
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]
Note, where more than one E.C. class is given (as above), each may correspond to a different protein domain or, in the case of polyprotein precursors, to a different mature protein.
Molecule diagrams generated from .mol files obtained from the KEGG ftp site

 

 
    reference    
 
 
Cell 147:209-222 (2011)
PubMed id: 21962517  
 
 
A pseudoatomic model of the dynamin polymer identifies a hydrolysis-dependent powerstroke.
J.S.Chappie, J.A.Mears, S.Fang, M.Leonard, S.L.Schmid, R.A.Milligan, J.E.Hinshaw, F.Dyda.
 
  ABSTRACT  
 
No abstract given.

 

 

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