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UniProt functional annotation for Q9Y2I2 | ||
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| UniProt code: Q9Y2I2. |
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| Organism: | |
Homo sapiens (Human). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. |
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| Function: | |
Involved in controlling patterning and neuronal circuit formation at the laminar, cellular, subcellular and synaptic levels. Promotes neurite outgrowth of both axons and dendrites. {ECO:0000269|PubMed:21946559}. |
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| Subunit: | |
Interacts with NGL1. {ECO:0000269|PubMed:14595443, ECO:0000269|PubMed:21946559}. |
| Subcellular location: | |
Cell membrane {ECO:0000269|PubMed:21946559}; Lipid-anchor, GPI-anchor {ECO:0000269|PubMed:21946559}; Extracellular side {ECO:0000269|PubMed:21946559}. |
| Tissue specificity: | |
Highly expressed in the thalamus, with very low expression, if any, in other tissues. {ECO:0000269|PubMed:14595443, ECO:0000269|PubMed:15901489}. |
| Domain: | |
The laminin N-terminal domain mediates 1:1 binding to NGL ligand with sub-micromolar affinity. Three NGL-binding loops mediate discrimination for LRRC4C/NGL1 among other NGLs by binding specifically to its LRR repeats. This specificity drives the sorting of a mixed population of molecules into discrete cell surface subdomains. |
| Ptm: | |
N-glycosylated. {ECO:0000250|UniProtKB:Q8R4G0}. |
| Miscellaneous: | |
[Isoform 3]: Mostly expressed in adult brain. |
| Miscellaneous: | |
[Isoform 1]: Hi expression in Expressed in brain and. {ECO:0000305}. |
| Miscellaneous: | |
[Isoform 4]: Mostly expressed in kidney, also expressed in adult and fetal brain. {ECO:0000305}. |
| Miscellaneous: | |
[Isoform 5]: Some expression in fetal brain. {ECO:0000305}. |
| Sequence caution: | |
Sequence=BAA76820.2; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305}; |
Annotations taken from UniProtKB at the EBI.