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UniProt functional annotation for Q9HCJ2 | ||
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| UniProt code: Q9HCJ2. |
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| Organism: | |
Homo sapiens (Human). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. |
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| Function: | |
May promote neurite outgrowth of developing thalamic neurons. {ECO:0000269|PubMed:14595443}. |
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| Subunit: | |
Interacts with NTNG1 and WHRN. {ECO:0000269|PubMed:14595443, ECO:0000269|PubMed:21946559}. |
| Subcellular location: | |
Cell junction, synapse, postsynaptic cell membrane {ECO:0000269|PubMed:14595443, ECO:0000269|PubMed:21946559}; Single-pass type I membrane protein {ECO:0000269|PubMed:14595443, ECO:0000269|PubMed:21946559}. |
| Tissue specificity: | |
Highly expressed in the cerebral cortex, including frontal, parietal and occipital lobes. Putamen, amygdala, hippocampus and medulla oblongata show moderate expression. Caudate nucleus and thalamus express small amounts, whereas other brain regions show very weak or no expression. {ECO:0000269|PubMed:14595443}. |
| Domain: | |
The LRR region is both necessary and sufficient for the interaction with NTNG1. |
Annotations taken from UniProtKB at the EBI.