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PDBsum entry 3zw3

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protein ligands links
Transferase PDB id
3zw3
Jmol PyMol
Contents
Protein chain
831 a.a.
Ligands
ZW3
Waters ×128
PDB id:
3zw3
Name: Transferase
Title: Fragment based discovery of a novel and selective pi3 kinase inhibitor
Structure: Phosphatidylinositol-4,5-bisphosphate 3-kinase ca subunit gamma isoform. Chain: a. Fragment: residues 144-1102. Synonym: phosphotidylinositol 3 kinase, pi3-kinase subunit pi3k-gamma, ptdins-3-kinase subunit gamma, phosphatidylinositol-4,5-bisphosphate 3-kinase 110 kda cat subunit gamma, ptdins-3-kinase subunit p110-gamma, p120-pi kinase gamma.
Source: Homo sapiens. Human. Organism_taxid: 9606
Resolution:
2.80Å     R-factor:   0.187     R-free:   0.210
Authors: D.G.Brown,S.J.Hughes,D.S.Milan,I.C.Kilty,R.A.Lewthwaite,J.P. M.A.Oreilly,A.Pannifer,A.Phelan,D.A.Baldock
Key ref: S.J.Hughes et al. (2011). Fragment based discovery of a novel and selective PI3 kinase inhibitor. Bioorg Med Chem Lett, 21, 6586-6590. PubMed id: 21925880 DOI: 10.1016/j.bmcl.2011.07.117
Date:
28-Jul-11     Release date:   28-Sep-11    
PROCHECK
Go to PROCHECK summary
 Headers
 References

Protein chain
Pfam  
-  (POLG_HAVHM) - 
Protein chain
Pfam   ArchSchema ?
P48736  (PK3CG_HUMAN) -  Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
Seq:
Struc:
 
Seq:
Struc:
 
Seq:
Struc:
1102 a.a.
831 a.a.
Key:    PfamA domain  Secondary structure  CATH domain

 Enzyme reactions 
   Enzyme class 2: E.C.2.7.1.153  - Phosphatidylinositol-4,5-bisphosphate 3-kinase.
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]

      Pathway:
1-Phosphatidyl-myo-inositol Metabolism
      Reaction: ATP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate = ADP + 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate
ATP
+ 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate
=
ADP
Bound ligand (Het Group name = ZW3)
matches with 41.18% similarity
+ 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate
   Enzyme class 3: E.C.2.7.11.1  - Non-specific serine/threonine protein kinase.
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]
      Reaction: ATP + a protein = ADP + a phosphoprotein
ATP
+ protein
=
ADP
Bound ligand (Het Group name = ZW3)
matches with 41.18% similarity
+ phosphoprotein
Note, where more than one E.C. class is given (as above), each may correspond to a different protein domain or, in the case of polyprotein precursors, to a different mature protein.
Molecule diagrams generated from .mol files obtained from the KEGG ftp site
 Gene Ontology (GO) functional annotation 
  GO annot!
  Biological process     phosphatidylinositol-mediated signaling   2 terms 
  Biochemical function     kinase activity     1 term  

 

 
    reference    
 
 
DOI no: 10.1016/j.bmcl.2011.07.117 Bioorg Med Chem Lett 21:6586-6590 (2011)
PubMed id: 21925880  
 
 
Fragment based discovery of a novel and selective PI3 kinase inhibitor.
S.J.Hughes, D.S.Millan, I.C.Kilty, R.A.Lewthwaite, J.P.Mathias, M.A.O'Reilly, A.Pannifer, A.Phelan, F.Stühmeier, D.A.Baldock, D.G.Brown.
 
  ABSTRACT  
 
No abstract given.

 

 

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