PDBsum entry 3zsg

Transferase

PDB id: 3zsg

Contents

Protein chain

337 a.a.

Ligands

T75

BOG

Waters ×317

PDB id:

3zsg

Name:

Transferase

Title:

X-ray structure of p38alpha bound to tak-715

Structure:

Mitogen-activated protein kinase 14. Chain: a. Synonym: map kinase 14, mapk 14, cytokine suppressive anti- inflammatory drug-binding protein, csaid-binding protein, csbp, map kinase mxi2, max-interacting protein 2, mitogen-activated protein kinase p38 alpha, map kinase p38 alpha, sapk2a, p38a. Engineered: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 469008. Expression_system_variant: rosetta.

Resolution:

1.89Å R-factor: 0.191 R-free: 0.233

Authors:

R.Azevedo,M.Van Zeeland,H.Raaijmakers,B.Kazemier,A.Oubrie

Key ref:

R.Azevedo et al. (2012). X-ray structure of p38α bound to TAK-715: comparison with three classic inhibitors. Acta Crystallogr D Biol Crystallogr, 68, 1041-1050. PubMed id: 22868770

Date:

28-Jun-11 Release date: 13-Jun-12

Protein chain

Q16539  (MK14_HUMAN) -  Mitogen-activated protein kinase 14 from Homo sapiens

Seq: 360 a.a.

Struc: 337 a.a.

Enzyme reactions

• Enzyme class: E.C.2.7.11.24 - mitogen-activated protein kinase.
• Reaction:
  1. L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H⁺
  2. L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H⁺

Molecule diagrams generated from .mol files obtained from the KEGG ftp site

reference

Acta Crystallogr D Biol Crystallogr 68:1041-1050 (2012)

PubMed id: 22868770

X-ray structure of p38α bound to TAK-715: comparison with three classic inhibitors.

R.Azevedo, M.van Zeeland, H.Raaijmakers, B.Kazemier, J.de Vlieg, A.Oubrie.

ABSTRACT

No abstract given.