PDBsum entry 3zrt

Signaling protein

PDB id: 3zrt

Contents

Protein chains

197 a.a.

121 a.a.

PDB id:

3zrt

Name:

Signaling protein

Title:

Crystal structure of human psd-95 pdz1-2

Structure:

Disks large homolog 4. Chain: a, b, c, d. Fragment: pdz1-2, reisdues 61-249. Synonym: postsynaptic density protein 95, psd-95, synapse-associated protein 90, sap-90, sap90. Engineered: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Expressed in: escherichia coli. Expression_system_taxid: 469008.

Resolution:

3.40Å R-factor: 0.221 R-free: 0.264

Authors:

P.L.Sorensen,J.S.Kastrup,M.Gajhede

Key ref:

A.Bach et al. (2012). A high-affinity, dimeric inhibitor of PSD-95 bivalently interacts with PDZ1-2 and protects against ischemic brain damage. Proc Natl Acad Sci U S A, 109, 3317-3322. PubMed id: 22343531

Date:

19-Jun-11 Release date: 21-Mar-12

Protein chains

P78352  (DLG4_HUMAN) -  Disks large homolog 4 from Homo sapiens

Seq: 724 a.a.

Struc: 197 a.a.*

Protein chain

P78352  (DLG4_HUMAN) -  Disks large homolog 4 from Homo sapiens

Seq: 724 a.a.

Struc: 121 a.a.*

* PDB and UniProt seqs differ at 17 residue positions (black crosses)

Enzyme reactions

• Enzyme class: Chains A, B, C, D: E.C.?

Proc Natl Acad Sci U S A 109:3317-3322 (2012)

PubMed id: 22343531

A high-affinity, dimeric inhibitor of PSD-95 bivalently interacts with PDZ1-2 and protects against ischemic brain damage.

A.Bach, B.H.Clausen, M.Møller, B.Vestergaard, C.N.Chi, A.Round, P.L.Sørensen, K.B.Nissen, J.S.Kastrup, M.Gajhede, P.Jemth, A.S.Kristensen, P.Lundström, K.L.Lambertsen, K.Strømgaard.

ABSTRACT

No abstract given.