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PDBsum entry 3zrm
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Transferase/peptide
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PDB id
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3zrm
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PDB id:
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| Name: |
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Transferase/peptide
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Title:
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Identification of 2-(4-pyridyl)thienopyridinones as gsk-3beta inhibitors
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Structure:
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Glycogen synthase kinase-3 beta. Chain: a, b. Fragment: residues 23-393. Synonym: gsk-3 beta. Engineered: yes. Proto-oncogene frat1. Chain: x, y. Fragment: residues 197-226. Synonym: frequently rearranged in advanced t-cell lymphomas 1, frat.
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Source:
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Homo sapiens. Human. Organism_taxid: 9606. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Expression_system_cell_line: sf9.
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Resolution:
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2.49Å
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R-factor:
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0.190
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R-free:
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0.247
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Authors:
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G.Gentile,G.Bernasconi,A.Pozzan,G.Merlo,P.Marzorati,P.Bamborough, B.Bax,A.Bridges,C.Brough,P.Carter,G.Cutler,M.Neu,M.Takada
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Key ref:
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G.Gentile
et al.
(2011).
Identification of 2-(4-pyridyl)thienopyridinones as GSK-3β inhibitors.
Bioorg Med Chem Lett,
21,
4823-4827.
PubMed id:
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Date:
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17-Jun-11
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Release date:
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29-Jun-11
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PROCHECK
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Headers
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References
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P49841
(GSK3B_HUMAN) -
Glycogen synthase kinase-3 beta from Homo sapiens
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Seq:
Struc:
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420 a.a.
346 a.a.
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Enzyme class 1:
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Chains A, B:
E.C.2.7.11.1
- non-specific serine/threonine protein kinase.
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Reaction:
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1.
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L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H+
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2.
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L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H+
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L-seryl-[protein]
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+
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ATP
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=
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O-phospho-L-seryl-[protein]
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+
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ADP
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+
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H(+)
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L-threonyl-[protein]
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+
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ATP
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=
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O-phospho-L-threonyl-[protein]
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+
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ADP
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+
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H(+)
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Enzyme class 2:
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Chains A, B:
E.C.2.7.11.26
- [tau protein] kinase.
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Reaction:
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1.
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L-seryl-[tau protein] + ATP = O-phospho-L-seryl-[tau protein] + ADP + H+
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2.
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L-threonyl-[tau protein] + ATP = O-phospho-L-threonyl-[tau protein] + ADP + H+
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L-seryl-[tau protein]
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+
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ATP
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=
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O-phospho-L-seryl-[tau protein]
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+
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ADP
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+
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H(+)
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L-threonyl-[tau protein]
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+
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ATP
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=
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O-phospho-L-threonyl-[tau protein]
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+
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ADP
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+
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H(+)
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Note, where more than one E.C. class is given (as above), each may
correspond to a different protein domain or, in the case of polyprotein
precursors, to a different mature protein.
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Molecule diagrams generated from .mol files obtained from the
KEGG ftp site
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Bioorg Med Chem Lett
21:4823-4827
(2011)
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PubMed id:
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Identification of 2-(4-pyridyl)thienopyridinones as GSK-3β inhibitors.
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G.Gentile,
G.Bernasconi,
A.Pozzan,
G.Merlo,
P.Marzorati,
P.Bamborough,
B.Bax,
A.Bridges,
C.Brough,
P.Carter,
G.Cutler,
M.Neu,
M.Takada.
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ABSTRACT
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