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UniProt functional annotation for Q96DX5 | ||
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| UniProt code: Q96DX5. |
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| Organism: | |
Homo sapiens (Human). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. |
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| Function: | |
Substrate-recognition component of a SCF-like ECS (Elongin- Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes at least two forms of creatine kinase, CKB and CKMT1A. {ECO:0000269|PubMed:22418839}. |
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| Pathway: | |
Protein modification; protein ubiquitination. |
| Subcellular location: | |
Mitochondrion {ECO:0000269|PubMed:20302626}. |
| Tissue specificity: | |
Predominantly expressed in testis, kidney, and liver. {ECO:0000269|PubMed:20302626}. |
| Domain: | |
The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin-protein ligase complexes. {ECO:0000250}. |
| Miscellaneous: | |
[Isoform 2]: Does not interact with the Elongin BC complex, likely to be a negative regulator of isoform 1. {ECO:0000305}. |
| Similarity: | |
Belongs to the ankyrin SOCS box (ASB) family. {ECO:0000305}. |
| Sequence caution: | |
Sequence=CAB45706.2; Type=Erroneous initiation; Evidence={ECO:0000305}; |
Annotations taken from UniProtKB at the EBI.