UniProt functional annotation for P15822



	UniProt functional annotation for P15822

UniProt code: P15822.

Organism: Homo sapiens (Human).

Taxonomy: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.

Function: This protein specifically binds to the DNA sequence 5'- GGGACTTTCC-3' which is found in the enhancer elements of numerous viral promoters such as those of SV40, CMV, or HIV-1. In addition, related sequences are found in the enhancer elements of a number of cellular promoters, including those of the class I MHC, interleukin-2 receptor, and interferon-beta genes. It may act in T-cell activation. Involved in activating HIV-1 gene expression. Isoform 2 and isoform 3 also bind to the IPCS (IRF1 and p53 common sequence) DNA sequence in the promoter region of interferon regulatory factor 1 and p53 genes and are involved in transcription regulation of these genes. Isoform 2 does not activate HIV-1 gene expression. Isoform 2 and isoform 3 may be involved in apoptosis.

Subunit: Interacts with UTP4. {ECO:0000269|PubMed:19732766}.

Subcellular location: [Isoform 1]: Nucleus.

Subcellular location: [Isoform 2]: Cytoplasm. Nucleus.

Subcellular location: [Isoform 3]: Cytoplasm {ECO:0000269|Ref.2}. Nucleus {ECO:0000269|Ref.2}.

Induction: By mitogens and phorbol ester.

Domain: Contains two sets of 2 zinc-fingers, which are widely separated and recognize the same DNA sequence. There is a fifth zinc-finger in- between.

Sequence caution: Sequence=CAA35798.1; Type=Frameshift; Evidence={ECO:0000305};

Annotations taken from UniProtKB at the EBI.


Organism:		Homo sapiens (Human).
Taxonomy:		Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.



Function:		This protein specifically binds to the DNA sequence 5'- GGGACTTTCC-3' which is found in the enhancer elements of numerous viral promoters such as those of SV40, CMV, or HIV-1. In addition, related sequences are found in the enhancer elements of a number of cellular promoters, including those of the class I MHC, interleukin-2 receptor, and interferon-beta genes. It may act in T-cell activation. Involved in activating HIV-1 gene expression. Isoform 2 and isoform 3 also bind to the IPCS (IRF1 and p53 common sequence) DNA sequence in the promoter region of interferon regulatory factor 1 and p53 genes and are involved in transcription regulation of these genes. Isoform 2 does not activate HIV-1 gene expression. Isoform 2 and isoform 3 may be involved in apoptosis.


Subunit:		Interacts with UTP4. {ECO:0000269\|PubMed:19732766}.
Subcellular location:		[Isoform 1]: Nucleus.
Subcellular location:		[Isoform 2]: Cytoplasm. Nucleus.
Subcellular location:		[Isoform 3]: Cytoplasm {ECO:0000269\|Ref.2}. Nucleus {ECO:0000269\|Ref.2}.
Induction:		By mitogens and phorbol ester.
Domain:		Contains two sets of 2 zinc-fingers, which are widely separated and recognize the same DNA sequence. There is a fifth zinc-finger in- between.
Sequence caution:		Sequence=CAA35798.1; Type=Frameshift; Evidence={ECO:0000305};