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UniProt functional annotation for P36980 | ||
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| UniProt code: P36980. |
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| Organism: | |
Homo sapiens (Human). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. |
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| Function: | |
Involved in complement regulation. The dimerized forms have avidity for tissue-bound complement fragments and efficiently compete with the physiological complement inhibitor CFH. Can associate with lipoproteins and may play a role in lipid metabolism. {ECO:0000269|PubMed:23487775}. |
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| Subunit: | |
Head-to-tail homodimer and heterodimer with CFHR1 or CFHR5. {ECO:0000269|PubMed:23487775}. |
| Subcellular location: | |
Secreted. |
| Tissue specificity: | |
Expressed by the liver and secreted in plasma. |
| Ptm: | |
N-glycosylated. {ECO:0000269|PubMed:1533657, ECO:0000269|PubMed:19159218}. |
Annotations taken from UniProtKB at the EBI.