UniProt functional annotation for P28738



	UniProt functional annotation for P28738

UniProt code: P28738.

Organism: Mus musculus (Mouse).

Taxonomy: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus.

Function: Involved in synaptic transmission (By similarity). Kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport. Mediates dendritic trafficking of mRNAs (PubMed:19608740). Required for anterograde axonal transportation of MAPK8IP3/JIP3 which is essential for MAPK8IP3/JIP3 function in axon elongation (By similarity). {ECO:0000250|UniProtKB:O60282, ECO:0000250|UniProtKB:P56536, ECO:0000269|PubMed:19608740}.

Subunit: Oligomer composed of two heavy chains and two light chains (PubMed:15286375). Interacts with GRIP1 (PubMed:11986669). Interacts with KLC3 and TRAK1 (By similarity). Interacts with ZFYVE27 (PubMed:21976701). {ECO:0000250|UniProtKB:O60282, ECO:0000250|UniProtKB:P56536, ECO:0000269|PubMed:11986669, ECO:0000269|PubMed:15286375, ECO:0000269|PubMed:21976701}.

Subcellular location: Cytoplasm, cytoskeleton {ECO:0000305}. Cell projection, dendrite {ECO:0000250|UniProtKB:O60282}. Note=Abundant in distal regions of dendrites. {ECO:0000250|UniProtKB:O60282}.

Domain: Composed of three structural domains: a large globular N- terminal domain which is responsible for the motor activity of kinesin (it hydrolyzes ATP and binds microtubule), a central alpha-helical coiled coil domain that mediates the heavy chain dimerization; and a small globular C-terminal domain which interacts with other proteins (such as the kinesin light chains), vesicles and membranous organelles.

Similarity: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. Kinesin subfamily. {ECO:0000255|PROSITE- ProRule:PRU00283}.

Sequence caution: Sequence=CAA43677.1; Type=Miscellaneous discrepancy; Note=Chimeric cDNA. The C-terminus (up to position 300) corresponds to KIF5C sequence.; Evidence={ECO:0000305};

Annotations taken from UniProtKB at the EBI.


Organism:		Mus musculus (Mouse).
Taxonomy:		Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus.



Function:		Involved in synaptic transmission (By similarity). Kinesin is a microtubule-associated force-producing protein that may play a role in organelle transport. Mediates dendritic trafficking of mRNAs (PubMed:19608740). Required for anterograde axonal transportation of MAPK8IP3/JIP3 which is essential for MAPK8IP3/JIP3 function in axon elongation (By similarity). {ECO:0000250\|UniProtKB:O60282, ECO:0000250\|UniProtKB:P56536, ECO:0000269\|PubMed:19608740}.


Subunit:		Oligomer composed of two heavy chains and two light chains (PubMed:15286375). Interacts with GRIP1 (PubMed:11986669). Interacts with KLC3 and TRAK1 (By similarity). Interacts with ZFYVE27 (PubMed:21976701). {ECO:0000250\|UniProtKB:O60282, ECO:0000250\|UniProtKB:P56536, ECO:0000269\|PubMed:11986669, ECO:0000269\|PubMed:15286375, ECO:0000269\|PubMed:21976701}.
Subcellular location:		Cytoplasm, cytoskeleton {ECO:0000305}. Cell projection, dendrite {ECO:0000250\|UniProtKB:O60282}. Note=Abundant in distal regions of dendrites. {ECO:0000250\|UniProtKB:O60282}.
Domain:		Composed of three structural domains: a large globular N- terminal domain which is responsible for the motor activity of kinesin (it hydrolyzes ATP and binds microtubule), a central alpha-helical coiled coil domain that mediates the heavy chain dimerization; and a small globular C-terminal domain which interacts with other proteins (such as the kinesin light chains), vesicles and membranous organelles.
Similarity:		Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. Kinesin subfamily. {ECO:0000255\|PROSITE- ProRule:PRU00283}.
Sequence caution:		Sequence=CAA43677.1; Type=Miscellaneous discrepancy; Note=Chimeric cDNA. The C-terminus (up to position 300) corresponds to KIF5C sequence.; Evidence={ECO:0000305};