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UniProt functional annotation for P31995 | ||
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| UniProt code: P31995. |
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| Organism: | |
Homo sapiens (Human). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. |
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| Function: | |
Receptor for the Fc region of complexed immunoglobulins gamma. Low affinity receptor. Involved in a variety of effector and regulatory functions such as phagocytosis of immune complexes and modulation of antibody production by B-cells. |
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| Subcellular location: | |
[Isoform IIC4]: Cytoplasm {ECO:0000305}. |
| Subcellular location: | |
[Isoform IIC3]: Cell membrane; Single-pass type I membrane protein. |
| Subcellular location: | |
[Isoform IIC2]: Cell membrane; Single-pass type I membrane protein. |
| Subcellular location: | |
[Isoform IIC1]: Cell membrane; Single-pass type I membrane protein. |
| Tissue specificity: | |
Isoform IIC1 is detected in monocytes, macrophages, polymorphonuclear cells and natural killer cells. |
| Domain: | |
Contains an intracytoplasmic twice repeated motif referred as immunoreceptor tyrosine-based activator motif (ITAM). These motifs are involved in triggering cell activation upon receptors aggregation. |
| Ptm: | |
Phosphorylated by SRC-type Tyr-kinases such as LYN, BLK, FYN and SYK. {ECO:0000269|PubMed:8756631}. |
| Sequence caution: | |
Sequence=CAA35643.1; Type=Erroneous initiation; Evidence={ECO:0000305}; |
Annotations taken from UniProtKB at the EBI.