UniProt functional annotation for Q69467



	UniProt functional annotation for Q69467

UniProt code: Q69467.

Organism: Human herpesvirus 2 (strain HG52) (HHV-2) (Human herpes simplex virus 2).

Taxonomy: Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes; Herpesvirales; Herpesviridae; Alphaherpesvirinae; Simplexvirus.

Function: Envelope glycoprotein that binds to the potential host cell entry receptors TNFRSF14/HVEM and NECTIN1. May trigger fusion with host membrane, by recruiting the fusion machinery composed of gB and gH/gL (By similarity). {ECO:0000250}.

Subunit: Homodimer (By similarity). Interacts with host receptor TNFRSF14. Interacts with host receptor NECTIN1. Interacts with host receptor NECTIN2. Interacts (via profusion domain) with gB; this interaction occurs in the absence of gH/gL. Interacts (via profusion domain) with gH/gL heterodimer; this interaction occurs in the absence of gB. Associates with the gB-gH/gL-gD complex. Interacts (via C- terminus) with UL11 tegument protein (By similarity). {ECO:0000250}.

Subcellular location: Virion membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Note=During virion morphogenesis, this protein probably accumulates in the endosomes and trans-Golgi where secondary envelopment occurs. {ECO:0000250}.

Similarity: Belongs to the herpesviridae glycoprotein D family. {ECO:0000305}.

Annotations taken from UniProtKB at the EBI.


Organism:		Human herpesvirus 2 (strain HG52) (HHV-2) (Human herpes simplex virus 2).
Taxonomy:		Viruses; Duplodnaviria; Heunggongvirae; Peploviricota; Herviviricetes; Herpesvirales; Herpesviridae; Alphaherpesvirinae; Simplexvirus.



Function:		Envelope glycoprotein that binds to the potential host cell entry receptors TNFRSF14/HVEM and NECTIN1. May trigger fusion with host membrane, by recruiting the fusion machinery composed of gB and gH/gL (By similarity). {ECO:0000250}.


Subunit:		Homodimer (By similarity). Interacts with host receptor TNFRSF14. Interacts with host receptor NECTIN1. Interacts with host receptor NECTIN2. Interacts (via profusion domain) with gB; this interaction occurs in the absence of gH/gL. Interacts (via profusion domain) with gH/gL heterodimer; this interaction occurs in the absence of gB. Associates with the gB-gH/gL-gD complex. Interacts (via C- terminus) with UL11 tegument protein (By similarity). {ECO:0000250}.
Subcellular location:		Virion membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Note=During virion morphogenesis, this protein probably accumulates in the endosomes and trans-Golgi where secondary envelopment occurs. {ECO:0000250}.
Similarity:		Belongs to the herpesviridae glycoprotein D family. {ECO:0000305}.