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PDBsum entry 3w3m
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Immune system
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PDB id
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3w3m
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References listed in PDB file
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Key reference
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Title
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Structural reorganization of the toll-Like receptor 8 dimer induced by agonistic ligands.
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Authors
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H.Tanji,
U.Ohto,
T.Shibata,
K.Miyake,
T.Shimizu.
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Ref.
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Science, 2013,
339,
1426-1429.
[DOI no: ]
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PubMed id
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Abstract
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Toll-like receptor 7 (TLR7) and TLR8 recognize single-stranded RNA and initiate
innate immune responses. Several synthetic agonists of TLR7-TLR8 display novel
therapeutic potential; however, the molecular basis for ligand recognition and
activation of signaling by TLR7 or TLR8 is largely unknown. In this study, the
crystal structures of unliganded and ligand-induced activated human TLR8 dimers
were elucidated. Ligand recognition was mediated by a dimerization interface
formed by two protomers. Upon ligand stimulation, the TLR8 dimer was reorganized
such that the two C termini were brought into proximity. The loop between
leucine-rich repeat 14 (LRR14) and LRR15 was cleaved; however, the N- and
C-terminal halves remained associated and contributed to ligand recognition and
dimerization. Thus, ligand binding induces reorganization of the TLR8 dimer,
which enables downstream signaling processes.
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