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PDBsum entry 3w2c
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PDB id:
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Transferase
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Title:
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Structure of aurora kinase a complexed to benzoimidazole-indazole inhibitor xv
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Structure:
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Aurora kinase a. Chain: a, c, e, g. Fragment: unp residues 128-388. Synonym: aurora 2, aurora/ipl1-related kinase 1, ark-1, aurora- related kinase 1, hark1, breast tumor-amplified kinase, serine/threonine-protein kinase 15, serine/threonine-protein kinase 6, serine/threonine-protein kinase aurora-a. Engineered: yes
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Source:
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Homo sapiens. Human. Organism_taxid: 9606. Gene: aurka, aik, airk1, ark1, aura, ayk1, btak, iak1, stk15, stk6. Expressed in: escherichia coli. Expression_system_taxid: 562
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Resolution:
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2.45Å
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R-factor:
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0.256
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R-free:
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0.320
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Authors:
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T.M.Oliveira,N.A.Kairies,R.A.Engh
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Key ref:
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T.M.Oliveira
et al.
Flexibility and multiple conformations of the activat glycine rich loops of aurora a accompanying inhibitor binding.
To be published,
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Date:
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28-Nov-12
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Release date:
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05-Feb-14
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PROCHECK
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Headers
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References
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O14965
(AURKA_HUMAN) -
Aurora kinase A from Homo sapiens
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Seq:
Struc:
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403 a.a.
203 a.a.
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Key: |
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PfamA domain |
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Secondary structure |
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CATH domain |
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Enzyme class:
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E.C.2.7.11.1
- non-specific serine/threonine protein kinase.
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Reaction:
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1.
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L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H+
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2.
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L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H+
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L-seryl-[protein]
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+
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ATP
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=
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O-phospho-L-seryl-[protein]
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+
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ADP
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+
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H(+)
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L-threonyl-[protein]
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+
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ATP
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=
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O-phospho-L-threonyl-[protein]
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+
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ADP
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+
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H(+)
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Molecule diagrams generated from .mol files obtained from the
KEGG ftp site
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Links
