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PDBsum entry 3w18
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protein ligands Protein-protein interface(s) links
Transferase/transferase inhibitor PDB id
3w18

 

 

 

 

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JSmol PyMol  
Contents
Protein chains
234 a.a.
Ligands
N13 ×2
Waters ×81
PDB id:
3w18
Name: Transferase/transferase inhibitor
Title: Structure of aurora kinase a complexed to benzoimidazole-indazole inhibitor xiii
Structure: Aurora kinase a. Chain: a, b. Fragment: domain, unp residues 126-403. Synonym: aurora 2, aurora/ipl1-related kinase 1, ark-1, aurora- related kinase 1, hark1, breast tumor-amplified kinase, serine/threonine-protein kinase 15, serine/threonine-protein kinase 6, serine/threonine-protein kinase aurora-a. Engineered: yes
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: aurka, aik, airk1, ark1, aura, ayk1, btak, iak1, stk15, stk6. Expressed in: escherichia coli. Expression_system_taxid: 562
Resolution:
2.50Å     R-factor:   0.244     R-free:   0.315
Authors: T.M.Oliveira,N.A.Kairies,R.A.Engh
Key ref: T.M.Oliveira et al. Flexibility and multiple conformations of the activat glycine rich loops of aurora a accompanying inhibitor binding. To be published, .
Date:
09-Nov-12     Release date:   05-Feb-14    
PROCHECK
Go to PROCHECK summary
 Headers
 References

Protein chains
Pfam   ArchSchema ?
O14965  (AURKA_HUMAN) -  Aurora kinase A from Homo sapiens
Seq:
Struc: 		403 a.a.
234 a.a.
Key:    PfamA domain  Secondary structure  CATH domain

 Enzyme reactions 
   Enzyme class: E.C.2.7.11.1  - non-specific serine/threonine protein kinase.
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]
      Reaction:
1. L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H+
2. L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H+
L-seryl-[protein]
 + ATP
 = O-phospho-L-seryl-[protein]
 + ADP
 + H(+)
L-threonyl-[protein]
 + ATP
 = O-phospho-L-threonyl-[protein]
 + ADP
 + H(+)
Molecule diagrams generated from .mol files obtained from the KEGG ftp site

 

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