PDBsum entry 3vq1

Immune system

PDB id: 3vq1

Contents

Protein chains

596 a.a.

135 a.a.

Ligands

NAG-NAG ×3

NAG ×2

LP4-LP5 ×2

Waters ×37

PDB id:

3vq1

Name:

Immune system

Title:

Crystal structure of mouse tlr4/md-2/lipid iva complex

Structure:

Toll-like receptor 4. Chain: a, b. Fragment: unp residues 22-627. Synonym: tlr4. Engineered: yes. Lymphocyte antigen 96. Chain: c, d. Synonym: ly-96, esop-1, protein md-2. Engineered: yes

Source:

Mus musculus. Mouse. Organism_taxid: 10090. Gene: tlr4. Expressed in: drosophila. Expression_system_taxid: 7215. Expression_system_cell: s2. Gene: md2. Expression_system_cell: s2

Resolution:

2.70Å R-factor: 0.236 R-free: 0.277

Authors:

U.Ohto,T.Shimizu

Key ref:

U.Ohto et al. (2012). Structural basis of species-specific endotoxin sensing by innate immune receptor TLR4/MD-2. Proc Natl Acad Sci U S A, 109, 7421-7426. PubMed id: 22532668

Date:

17-Mar-12 Release date: 09-May-12

Protein chains

Q9QUK6  (TLR4_MOUSE) -  Toll-like receptor 4 from Mus musculus

Seq: 835 a.a.

Struc: 596 a.a.

Protein chains

Q9JHF9  (LY96_MOUSE) -  Lymphocyte antigen 96 from Mus musculus

Seq: 160 a.a.

Struc: 135 a.a.

Enzyme reactions

• Enzyme class: Chains A, B: E.C.3.2.2.6 - ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase.
• Reaction: NAD⁺ + H2O = ADP-D-ribose + nicotinamide + H⁺

NAD(+) + H2O = ADP-D-ribose + nicotinamide + H(+) (Bound ligand (Het Group name = NAG) matches with 43.75% similarity)

Molecule diagrams generated from .mol files obtained from the KEGG ftp site

reference

Proc Natl Acad Sci U S A 109:7421-7426 (2012)

PubMed id: 22532668

Structural basis of species-specific endotoxin sensing by innate immune receptor TLR4/MD-2.

U.Ohto, K.Fukase, K.Miyake, T.Shimizu.

ABSTRACT

No abstract given.