spacer
spacer

PDBsum entry 3vn2

Go to PDB code: 
protein ligands Protein-protein interface(s) links
Signaling protein PDB id
3vn2
Jmol PyMol
Contents
Protein chains
261 a.a.
11 a.a.
Ligands
TLS
Waters ×47
PDB id:
3vn2
Name: Signaling protein
Title: Crystal structure of ppargamma complexed with telmisartan
Structure: Peroxisome proliferator-activated receptor gamma. Chain: a. Fragment: ligand biding domain, unp residues 225-505. Synonym: ppar-gamma, nuclear receptor subfamily 1 group c m engineered: yes. Nuclear receptor coactivator 1. Chain: c. Fragment: coactivator fragment src-1, unp residues 685-700. Synonym: ncoa-1, class e basic helix-loop-helix protein 74,
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: pparg. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Organism_taxid: 9606
Resolution:
2.18Å     R-factor:   0.253     R-free:   0.309
Authors: Y.Amano
Key ref: Y.Amano et al. (2012). Structural basis for telmisartan-mediated partial activation of PPAR gamma. Hypertens Res, 35, 715-719. PubMed id: 22357520 DOI: 10.1038/hr.2012.17
Date:
21-Dec-11     Release date:   07-Mar-12    
PROCHECK
Go to PROCHECK summary
 Headers
 References

Protein chain
Pfam   ArchSchema ?
P37231  (PPARG_HUMAN) -  Peroxisome proliferator-activated receptor gamma
Seq:
Struc:
505 a.a.
261 a.a.
Protein chain
Pfam   ArchSchema ?
Q15788  (NCOA1_HUMAN) -  Nuclear receptor coactivator 1
Seq:
Struc:
 
Seq:
Struc:
 
Seq:
Struc:
1441 a.a.
11 a.a.
Key:    PfamA domain  Secondary structure  CATH domain

 Gene Ontology (GO) functional annotation 
  GO annot!
  Cellular component     nucleus   1 term 
  Biological process     steroid hormone mediated signaling pathway   2 terms 
  Biochemical function     DNA binding     3 terms  

 

 
DOI no: 10.1038/hr.2012.17 Hypertens Res 35:715-719 (2012)
PubMed id: 22357520  
 
 
Structural basis for telmisartan-mediated partial activation of PPAR gamma.
Y.Amano, T.Yamaguchi, K.Ohno, T.Niimi, M.Orita, H.Sakashita, M.Takeuchi.
 
  ABSTRACT  
 
No abstract given.

 

 

spacer

spacer