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PDBsum entry 3vi8

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protein ligands links
Transcription PDB id
3vi8
Jmol PyMol
Contents
Protein chain
258 a.a.
Ligands
13M
Waters ×172
PDB id:
3vi8
Name: Transcription
Title: Human ppar alpha ligand binding domain in complex with a syn agonist aphm13
Structure: Peroxisome proliferator-activated receptor alpha. Chain: a. Fragment: ligand binding domain. Synonym: ppar-alpha, nuclear receptor subfamily 1 group c m engineered: yes
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ppara. Expressed in: escherichia coli. Expression_system_taxid: 562.
Resolution:
1.75Å     R-factor:   0.214     R-free:   0.249
Authors: T.Oyama,H.Miyachi,K.Morikawa
Key ref: N.Kuwabara et al. (2012). Peroxisome proliferator-activated receptors (PPARs) have multiple binding points that accommodate ligands in various conformations: phenylpropanoic acid-type PPAR ligands bind to PPAR in different conformations, depending on the subtype. J Med Chem, 55, 893-902. PubMed id: 22185225 DOI: 10.1021/jm2014293
Date:
25-Sep-11     Release date:   29-Aug-12    
PROCHECK
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 Headers
 References

Protein chain
Pfam   ArchSchema ?
Q07869  (PPARA_HUMAN) -  Peroxisome proliferator-activated receptor alpha
Seq:
Struc:
468 a.a.
258 a.a.
Key:    PfamA domain  Secondary structure  CATH domain

 Gene Ontology (GO) functional annotation 
  GO annot!
  Cellular component     nucleus   1 term 
  Biological process     steroid hormone mediated signaling pathway   2 terms 
  Biochemical function     DNA binding     3 terms  

 

 
DOI no: 10.1021/jm2014293 J Med Chem 55:893-902 (2012)
PubMed id: 22185225  
 
 
Peroxisome proliferator-activated receptors (PPARs) have multiple binding points that accommodate ligands in various conformations: phenylpropanoic acid-type PPAR ligands bind to PPAR in different conformations, depending on the subtype.
N.Kuwabara, T.Oyama, D.Tomioka, M.Ohashi, J.Yanagisawa, T.Shimizu, H.Miyachi.
 
  ABSTRACT  
 
No abstract given.

 

 

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