PDBsum entry 3v6r

Transferase/transferase inhibitor

PDB id: 3v6r

Contents

Protein chains

350 a.a.

Ligands

CQQ ×2

Waters ×255

PDB id:

3v6r

Name:

Transferase/transferase inhibitor

Title:

Discovery of potent and selective covalent inhibitors of jnk

Structure:

Mitogen-activated protein kinase 10. Chain: a, b. Synonym: map kinase 10, mapk 10, map kinase p49 3f12, stress- activated protein kinase 1b, sapk1b, stress-activated protein kinase jnk3, c-jun n-terminal kinase 3. Engineered: yes

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: mapk10, jnk3, jnk3a, prkm10, sapk1b. Expressed in: escherichia coli. Expression_system_taxid: 562

Resolution:

2.60Å R-factor: 0.210 R-free: 0.264

Authors:

H.Park,P.V.Lograsso,J.D.Laughlin

Key ref:

T.Zhang et al. (2012). Discovery of potent and selective covalent inhibitors of JNK. Chem Biol, 19, 140-154. PubMed id: 22284361

Date:

20-Dec-11 Release date: 01-Feb-12

Protein chains

P53779  (MK10_HUMAN) -  Mitogen-activated protein kinase 10 from Homo sapiens

Seq: 464 a.a.

Struc: 350 a.a.

Enzyme reactions

• Enzyme class: E.C.2.7.11.24 - mitogen-activated protein kinase.
• Reaction:
  1. L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H⁺
  2. L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H⁺

Molecule diagrams generated from .mol files obtained from the KEGG ftp site

reference

Chem Biol 19:140-154 (2012)

PubMed id: 22284361

Discovery of potent and selective covalent inhibitors of JNK.

T.Zhang, F.Inesta-Vaquera, M.Niepel, J.Zhang, S.B.Ficarro, T.Machleidt, T.Xie, J.A.Marto, N.Kim, T.Sim, J.D.Laughlin, H.Park, P.V.LoGrasso, M.Patricelli, T.K.Nomanbhoy, P.K.Sorger, D.R.Alessi, N.S.Gray.

ABSTRACT

No abstract given.