PDBsum entry 3v6o

Immune system

PDB id: 3v6o

Contents

Protein chains

181 a.a.

184 a.a.

220 a.a.

213 a.a.

Ligands

CYS ×2

EDO ×31

ACT ×6

NAG

Metals

_NA

Waters ×851

PDB id:

3v6o

Name:

Immune system

Title:

Leptin receptor-antibody complex

Structure:

Leptin receptor. Chain: a, b. Fragment: leptin binding domain of human obesity receptor. Synonym: lep-r, hub219, ob receptor, ob-r. Engineered: yes. Monoclonal antibody 9f8 fab fragment heavy chain. Chain: c, d. Fragment: fab fragment of monoclonal antibody h chain. Monoclonal antibody 9f8 fab fragment light chain.

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: db, lepr, obr. Expressed in: escherichia coli. Expression_system_taxid: 562. Mus musculus. Organism_taxid: 10090. Organism_taxid: 10090

Resolution:

1.95Å R-factor: 0.174 R-free: 0.214

Authors:

B.Carpenter,G.R.Hemsworth,R.J.Ross,P.J.Artymiuk

Key ref:

B.Carpenter et al. (2012). Structure of the human obesity receptor leptin-binding domain reveals the mechanism of leptin antagonism by a monoclonal antibody. Structure, 20, 487-497. PubMed id: 22405007

Date:

20-Dec-11 Release date: 14-Mar-12

Protein chain

P48357  (LEPR_HUMAN) -  Leptin receptor from Homo sapiens

Seq: 1165 a.a.

Struc: 181 a.a.

Protein chain

P48357  (LEPR_HUMAN) -  Leptin receptor from Homo sapiens

Seq: 1165 a.a.

Struc: 184 a.a.

Protein chains

No UniProt id for this chain

Struc: 220 a.a.

Protein chains

No UniProt id for this chain

Struc: 213 a.a.

Structure 20:487-497 (2012)

PubMed id: 22405007

Structure of the human obesity receptor leptin-binding domain reveals the mechanism of leptin antagonism by a monoclonal antibody.

B.Carpenter, G.R.Hemsworth, Z.Wu, M.Maamra, C.J.Strasburger, R.J.Ross, P.J.Artymiuk.

ABSTRACT

No abstract given.