PDBsum entry 3v4v

Cell adhesion

PDB id: 3v4v

Contents

Protein chains

582 a.a.

375 a.a.

211 a.a.

217 a.a.

Ligands

NAG-NAG-BMA-MAN ×2

NAG ×11

TRS

0DU ×2

Metals

_CA ×10

_MG ×2

Waters ×31

PDB id:

3v4v

Name:

Cell adhesion

Title:

Crystal structure of a4b7 headpiece complexed with fab act-1 and ro0505376

Structure:

Integrin alpha-4. Chain: a, c. Fragment: unp residues 34-620. Synonym: cd49 antigen-like family member d, integrin alpha-iv, vla-4 subunit alpha. Engineered: yes. Mutation: yes. Integrin beta-7. Chain: b, d.

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: itga4, cd49d. Expressed in: cricetulus griseus. Expression_system_taxid: 10029. Expression_system_cell_line: cho. Gene: itgb7. Mus musculus.

Resolution:

3.10Å R-factor: 0.198 R-free: 0.231

Authors:

Y.Yu,J.Zhu,T.A.Springer

Key ref:

Y.Yu et al. (2012). Structural specializations of α(4)β(7), an integrin that mediates rolling adhesion. J Cell Biol, 196, 131-146. PubMed id: 22232704

Date:

15-Dec-11 Release date: 11-Jan-12

Protein chains

P13612  (ITA4_HUMAN) -  Integrin alpha-4 from Homo sapiens

Seq: 1032 a.a.

Struc: 582 a.a.

Protein chains

P26010  (ITB7_HUMAN) -  Integrin beta-7 from Homo sapiens

Seq: 798 a.a.

Struc: 375 a.a.

Protein chains

No UniProt id for this chain

Struc: 211 a.a.

Protein chains

No UniProt id for this chain

Struc: 217 a.a.

J Cell Biol 196:131-146 (2012)

PubMed id: 22232704

Structural specializations of α(4)β(7), an integrin that mediates rolling adhesion.

Y.Yu, J.Zhu, L.Z.Mi, T.Walz, H.Sun, J.Chen, T.A.Springer.

ABSTRACT

No abstract given.