PDBsum entry 3v4u

Immune system

PDB id

3v4u

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Contents

			Protein chains

					216 a.a.


					218 a.a.

			Ligands

					GLU-PRO-GLN-ALA- PRO-TRP-MET-GLU

			Waters ×355

PDB id:

3v4u

Links

Name:

Immune system

Title:

Structure of a monoclonal antibody complexed with its mhc-i antigen

Structure:

Anti-mhc-i monoclonal antibody, 64-3-7 h chain. Chain: h. Anti-mhc-i monoclonal antibody, 64-3-7 l chain. Chain: l. H-2 class i histocompatibility antigen, l-d alpha chain. Chain: p. Fragment: h-2l(d) peptide segment 46-54. Engineered: yes

Source:

Mus musculus. Mouse. Organism_taxid: 10090. Synthetic: yes. Other_details: synthetic peptide

Resolution:

1.64Å

R-factor:

0.215

R-free:

0.251

Authors:

D.H.Margulies,M.G.Mage,R.Wang,K.Natarajan

Key ref:

M.G.Mage et al. (2012). The peptide-receptive transition state of MHC class I molecules: insight from structure and molecular dynamics. J Immunol, 189, 1391-1399. PubMed id: 22753930

Date:

15-Dec-11

Release date:

25-Jul-12

PROCHECK

	Headers

	References

Protein chain

No UniProt id for this chain

Struc:					216 a.a.

Protein chain

A2NHM3 (A2NHM3_MOUSE) - If kappa light chain (Fragment) from Mus musculus

Seq: Struc:					219 a.a. 218 a.a.*

Key:

PfamA domain

Secondary structure

CATH domain

* PDB and UniProt seqs differ at 9 residue positions (black crosses)

	J Immunol 189:1391-1399 (2012)
PubMed id: 22753930

The peptide-receptive transition state of MHC class I molecules: insight from structure and molecular dynamics.
M.G.Mage, M.A.Dolan, R.Wang, L.F.Boyd, M.J.Revilleza, H.Robinson, K.Natarajan, N.B.Myers, T.H.Hansen, D.H.Margulies.

ABSTRACT

No abstract given.

Literature references that cite this PDB file's key reference

PubMed id

Reference

23042604

L.Li, Y.Muzahim, and M.Bouvier (2012).
Crystal structure of adenovirus E3-19K bound to HLA-A2 reveals mechanism for immunomodulation.

Nat Struct Mol Biol, 19, 1176-1181.

PDB code:

4e5x

The most recent references are shown first. Citation data come partly from CiteXplore and partly from an automated harvesting procedure. Note that this is likely to be only a partial list as not all journals are covered by either method. However, we are continually building up the citation data so more and more references will be included with time. Where a reference describes a PDB structure, the PDB code is shown on the right.