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UniProt functional annotation for Q45914 | ||
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| UniProt code: Q45914. |
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| Organism: | |
Clostridium botulinum. |
| Taxonomy: | |
Bacteria; Firmicutes; Clostridia; Eubacteriales; Clostridiaceae; Clostridium. |
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| Function: | |
Assembles with botulinum neurotoxin type A (BoNT/A) and protects it against pH-mediated inactivation or protease activity at pH 2.6 (the pH of the animal gastrointestinal tract) but not at pH 6.0 (PubMed:22363010). Necessary for neurotoxicity. {ECO:0000269|PubMed:22363010}. |
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| Subunit: | |
Forms a highly interlocked heterodimer with botulinum neurotoxin type A at pH 6.0 but not at pH 7.5, called the minimally functional progenitor toxin complex (M-PTC) (BoNT/A, botA) (PubMed:22363010). |
| Domain: | |
Has 3 domains that are structurally very similar to those in BoNT/A; light chain (nLC, equivalent to the light chain, residues 1- 408), N-heavy chain (nHN, residues 409-829) and C-heavy chain (nHC, residues 830-1193) (PubMed:22363010). {ECO:0000269|PubMed:22363010}. |
| Ptm: | |
The 133-Lys-|-Lys-134 bond is cleaved during long-term storage; the cleavage site is masked in the M-PTC complex (PubMed:22363010). {ECO:0000269|PubMed:22363010}. |
| Similarity: | |
Belongs to the botulism non-toxic nonhemagglutinin family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.