PDBsum entry 3uzt

Transferase/RNA

PDB id: 3uzt

Contents

Protein chain

586 a.a.

DNA/RNA

Metals

_MG

PDB id:

3uzt

Name:

Transferase/RNA

Title:

Structure of the c13.18 RNA aptamer in complex with g protein-coupled receptor kinase 2

Structure:

Beta-adrenergic receptor kinase 1. Chain: a. Synonym: beta-ark-1, g-protein-coupled receptor kinase 2. Engineered: yes. Mutation: yes. C13.18 RNA aptamer. Chain: b. Engineered: yes

Source:

Bos taurus. Bovine. Organism_taxid: 9913. Gene: adrbk1, grk2. Expressed in: spodoptera frugiperda. Expression_system_taxid: 7108. Synthetic: yes. Other_details: synthetic RNA polymer, no 5' or 3' phosphates

Resolution:

3.51Å R-factor: 0.220 R-free: 0.317

Authors:

J.J.G.Tesmer,V.M.Tesmer

Key ref:

V.M.Tesmer et al. (2012). Molecular mechanism for inhibition of g protein-coupled receptor kinase 2 by a selective RNA aptamer. Structure, 20, 1300-1309. PubMed id: 22727813

Date:

07-Dec-11 Release date: 11-Jul-12

Protein chain

P21146  (ARBK1_BOVIN) -  Beta-adrenergic receptor kinase 1 from Bos taurus

Seq: 689 a.a.

Struc: 586 a.a.

DNA/RNA chain

C-C-A-U-A-C-G 7 bases

Enzyme reactions

• Enzyme class: E.C.2.7.11.15 - [beta-adrenergic-receptor] kinase.
• Reaction: [beta-adrenergic receptor] + ATP = [beta-adrenergic receptor]-phosphate + ADP + H⁺

Molecule diagrams generated from .mol files obtained from the KEGG ftp site

reference

Structure 20:1300-1309 (2012)

PubMed id: 22727813

Molecular mechanism for inhibition of g protein-coupled receptor kinase 2 by a selective RNA aptamer.

V.M.Tesmer, S.Lennarz, G.Mayer, J.J.Tesmer.

ABSTRACT

No abstract given.