 |
PDBsum entry 3uw9
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Protein binding
|
PDB id
|
|
|
|
3uw9
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PDB id:
|
|
|
|
| Name: |
|
Protein binding
|
|
|
Title:
|
|
Crystal structure of the first bromodomain of human brd4 in complex with a diacetylated histone 4 peptide (h4k8ack12ac)
|
|
Structure:
|
|
Bromodomain-containing protein 4. Chain: a, b, c, d. Fragment: unp resideus 44-168. Synonym: protein hunk1. Engineered: yes. Histone 4 peptide (h4k8ack12ac). Chain: e, f. Fragment: unp residues 8-18. Synonym: peptide (h4k8ack12ac).
|
|
Source:
|
|
Homo sapiens. Human. Organism_taxid: 9606. Gene: brd4, hunk1. Expressed in: escherichia coli. Expression_system_taxid: 469008. Synthetic: yes. Organism_taxid: 9606
|
|
Resolution:
|
|
|
2.30Å
|
R-factor:
|
0.203
|
R-free:
|
0.257
|
|
|
Authors:
|
|
P.Filippakopoulos,I.Felletar,S.Picaud,T.Keates,J.Muniz,O.Gileadi, F.Von Delft,C.H.Arrowsmith,A.M.Edwards,J.Weigelt,C.Bountra,S.Knapp, Structural Genomics Consortium (Sgc)
|
|
Key ref:
|
|
P.Filippakopoulos
et al.
(2012).
Histone recognition and large-scale structural analysis of the human bromodomain family.
Cell,
149,
214-231.
PubMed id:
|
|
|
Date:
|
|
|
01-Dec-11
|
Release date:
|
14-Mar-12
|
|
|
|
|
|
|
PROCHECK
|
|
|
|
|
|
Headers
|
|
|
|
References
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
 |
|
|
|
|
|
|
| |
|
|
Cell
149:214-231
(2012)
|
|
PubMed id:
|
|
|
|
|
|
| |
|
Histone recognition and large-scale structural analysis of the human bromodomain family.
|
|
P.Filippakopoulos,
S.Picaud,
M.Mangos,
T.Keates,
J.P.Lambert,
D.Barsyte-Lovejoy,
I.Felletar,
R.Volkmer,
S.Müller,
T.Pawson,
A.C.Gingras,
C.H.Arrowsmith,
S.Knapp.
|
|
|
|
|
| |
ABSTRACT
|
|
|
|
| |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
 |
 |
 |
|
Literature references that cite this PDB file's key reference
|
|
|
| |
PubMed id
|
|
Reference
|
|
|
|
|
|
C.A.Musselman,
M.E.Lalonde,
J.Côté,
and
T.G.Kutateladze
(2012).
Perceiving the epigenetic landscape through histone readers.
|
| |
Nat Struct Mol Biol,
19,
1218-1227.
|
|
|
|
|
|
The most recent references are shown first.
Citation data come partly from CiteXplore and partly
from an automated harvesting procedure. Note that this is likely to be
only a partial list as not all journals are covered by
either method. However, we are continually building up the citation data
so more and more references will be included with time.
|
|
|
Links
