 |
PDBsum entry 3uvx
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
 |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Transcription/protein binding
|
PDB id
|
|
|
|
3uvx
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PDB id:
|
|
|
|
| Name: |
|
Transcription/protein binding
|
|
|
Title:
|
|
Crystal structure of the first bromodomain of human brd4 in complex with a diacetylated histone 4 peptide (h4k12ack16ac)
|
|
Structure:
|
|
Bromodomain-containing protein 4. Chain: a. Fragment: unp residues 44-168. Synonym: protein hunk1. Engineered: yes. Diacetylated histone 4 peptide. Chain: b. Synonym: peptide (h4k12ack16ac). Engineered: yes
|
|
Source:
|
|
Homo sapiens. Human. Organism_taxid: 9606. Gene: brd4, hunk1. Expressed in: escherichia coli. Expression_system_taxid: 469008. Synthetic: yes. Other_details: human histone 4 peptide (uniprot: p62805) residues 11-21 acetylated on k12 and k16
|
|
Resolution:
|
|
|
1.91Å
|
R-factor:
|
0.170
|
R-free:
|
0.219
|
|
|
Authors:
|
|
P.Filippakopoulos,S.Picaud,T.Keates,E.Ugochukwu,F.Von Delft, C.H.Arrowsmith,A.M.Edwards,J.Weigelt,C.Bountra,S.Knapp,Structural Genomics Consortium (Sgc)
|
|
Key ref:
|
|
P.Filippakopoulos
et al.
(2012).
Histone recognition and large-scale structural analysis of the human bromodomain family.
Cell,
149,
214-231.
PubMed id:
|
|
|
Date:
|
|
|
30-Nov-11
|
Release date:
|
25-Jan-12
|
|
|
|
|
|
|
PROCHECK
|
|
|
|
|
|
Headers
|
|
|
|
References
|
|
|
|
|
|
|
|
O60885
(BRD4_HUMAN) -
Bromodomain-containing protein 4 from Homo sapiens
|
|
|
|
Seq:
Struc:
|
|
|
|
1362 a.a.
127 a.a.*
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
Key: |
 |
PfamA domain |
|
|
 |
Secondary structure |
|
 |
CATH domain |
|
|
*
PDB and UniProt seqs differ
at 1 residue position (black
cross)
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
 |
|
|
|
|
|
|
| |
|
|
Cell
149:214-231
(2012)
|
|
PubMed id:
|
|
|
|
|
|
| |
|
Histone recognition and large-scale structural analysis of the human bromodomain family.
|
|
P.Filippakopoulos,
S.Picaud,
M.Mangos,
T.Keates,
J.P.Lambert,
D.Barsyte-Lovejoy,
I.Felletar,
R.Volkmer,
S.Müller,
T.Pawson,
A.C.Gingras,
C.H.Arrowsmith,
S.Knapp.
|
|
|
|
|
| |
ABSTRACT
|
|
|
|
| |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
 |
 |
 |
|
Literature references that cite this PDB file's key reference
|
|
|
| |
PubMed id
|
|
Reference
|
|
|
|
|
|
C.A.Musselman,
M.E.Lalonde,
J.Côté,
and
T.G.Kutateladze
(2012).
Perceiving the epigenetic landscape through histone readers.
|
| |
Nat Struct Mol Biol,
19,
1218-1227.
|
|
|
|
|
|
The most recent references are shown first.
Citation data come partly from CiteXplore and partly
from an automated harvesting procedure. Note that this is likely to be
only a partial list as not all journals are covered by
either method. However, we are continually building up the citation data
so more and more references will be included with time.
|
|
Links
