PDBsum entry 3uvl

Transcription

PDB id: 3uvl

Contents

Protein chain

303 a.a.

Ligands

GLY-SER-ALA-ARG-ALA-GLU-PRO-LYS-MET

Waters ×180

PDB id:

3uvl

Name:

Transcription

Title:

Crystal structure of wdr5 in complex with the wdr5-interacting motif of mll3

Structure:

Wd repeat-containing protein 5. Chain: a. Fragment: unp residues 21-334. Synonym: wdr5, bmp2-induced 3-kb gene protein. Engineered: yes. Histone-lysine n-methyltransferase mll3. Chain: b. Fragment: wdr5-interacting motif (unp residues 4707-4717). Synonym: homologous to alr protein, lysine n-methyltransferase 2c,

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: wdr5, big3. Expressed in: escherichia coli. Expression_system_taxid: 562. Synthetic: yes. Organism_taxid: 9606

Resolution:

2.20Å R-factor: 0.172 R-free: 0.220

Authors:

P.Zhang,H.Lee,J.S.Brunzelle,J.-F.Couture

Key ref:

P.Zhang et al. (2012). The plasticity of WDR5 peptide-binding cleft enables the binding of the SET1 family of histone methyltransferases. Nucleic Acids Res, 40, 4237-4246. PubMed id: 22266653

Date:

30-Nov-11 Release date: 14-Dec-11

Protein chain

P61964  (WDR5_HUMAN) -  WD repeat-containing protein 5 from Homo sapiens

Seq: 334 a.a.

Struc: 303 a.a.

Enzyme reactions

• Enzyme class: E.C.2.1.1.43 - Transferred entry: 2.1.1.354.
• Reaction: S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N₆-methyl-L-lysine-[histone]

Molecule diagrams generated from .mol files obtained from the KEGG ftp site

Added reference

Nucleic Acids Res 40:4237-4246 (2012)

PubMed id: 22266653

The plasticity of WDR5 peptide-binding cleft enables the binding of the SET1 family of histone methyltransferases.

P.Zhang, H.Lee, J.S.Brunzelle, J.F.Couture.

ABSTRACT

No abstract given.