PDBsum entry 3utt

Immune system

PDB id: 3utt

Contents

Protein chains

275 a.a.

100 a.a.

199 a.a.

244 a.a.

Ligands

ALA-LEU-TRP-GLY-PRO-ASP-PRO-ALA-ALA-ALA ×2

Waters ×151

PDB id:

3utt

Name:

Immune system

Title:

1e6-a 0201-Alwgpdpaaa complex, triclinic

Structure:

Hla class i histocompatibility antigen, a-2 alpha chain. Chain: a, f. Fragment: unp residues 25-299. Synonym: mhc class i heavy chain, mhc class i antigen a 2. Engineered: yes. Beta-2-microglobulin. Chain: b, g. Fragment: unp residues 21-119. Engineered: yes.

Source:

Homo sapiens. Human. Organism_taxid: 9606. Gene: hla-a, hlaa. Expressed in: escherichia coli. Expression_system_taxid: 562. Gene: b2m, cdabp0092, hdcma22p. Synthetic: yes.

Resolution:

2.60Å R-factor: 0.199 R-free: 0.274

Authors:

P.J.Rizkallah,D.K.Cole,A.K.Sewell,A.M.Bulek,J.Rossjohn,S.Gras

Key ref:

A.M.Bulek et al. (2012). Structural basis for the killing of human beta cells by CD8(+) T cells in type 1 diabetes. Nat Immunol, 13, 283-289. PubMed id: 22245737

Date:

26-Nov-11 Release date: 25-Jan-12

Protein chains

P04439  (1A03_HUMAN) -  HLA class I histocompatibility antigen, A alpha chain from Homo sapiens

Seq: 365 a.a.

Struc: 275 a.a.*

Protein chains

P61769  (B2MG_HUMAN) -  Beta-2-microglobulin from Homo sapiens

Seq: 119 a.a.

Struc: 100 a.a.*

Protein chains

No UniProt id for this chain

Struc: 199 a.a.

Protein chains

No UniProt id for this chain

Struc: 244 a.a.

* PDB and UniProt seqs differ at 20 residue positions (black crosses)

Nat Immunol 13:283-289 (2012)

PubMed id: 22245737

Structural basis for the killing of human beta cells by CD8(+) T cells in type 1 diabetes.

A.M.Bulek, D.K.Cole, A.Skowera, G.Dolton, S.Gras, F.Madura, A.Fuller, J.J.Miles, E.Gostick, D.A.Price, J.W.Drijfhout, R.R.Knight, G.C.Huang, N.Lissin, P.E.Molloy, L.Wooldridge, B.K.Jakobsen, J.Rossjohn, M.Peakman, P.J.Rizkallah, A.K.Sewell.

ABSTRACT

No abstract given.