PDBsum entry 3uto

Transferase

PDB id: 3uto

Contents

Protein chains

559 a.a.

Ligands

GOL

PEG

FLC

P33

Waters ×424

PDB id:

3uto

Name:

Transferase

Title:

Twitchin kinase region from c.Elegans (fn31-nl-kin-crd-ig26)

Structure:

Twitchin. Chain: a, b. Fragment: twitchin kinase region (fn3-nl-kin-crd-ig), unp residues 6108-6675. Synonym: uncoordinated protein 22. Engineered: yes

Source:

Caenorhabditis elegans. Nematode. Organism_taxid: 6239. Gene: unc-22, zk617.1. Expressed in: escherichia coli. Expression_system_taxid: 562.

Resolution:

2.40Å R-factor: 0.176 R-free: 0.213

Authors:

E.Castelmur,S.Barbieri,O.Mayans

Key ref:

E.von Castelmur et al. (2012). Identification of an N-terminal inhibitory extension as the primary mechanosensory regulator of twitchin kinase. Proc Natl Acad Sci U S A, 109, 13608-13613. PubMed id: 22869697

Date:

26-Nov-11 Release date: 08-Aug-12

Protein chains

Q23551  (UNC22_CAEEL) -  Twitchin from Caenorhabditis elegans

Seq: 7158 a.a.

Struc: 559 a.a.*

* PDB and UniProt seqs differ at 2 residue positions (black crosses)

Enzyme reactions

• Enzyme class: E.C.2.7.11.1 - non-specific serine/threonine protein kinase.
• Reaction:
  1. L-seryl-[protein] + ATP = O-phospho-L-seryl-[protein] + ADP + H⁺
  2. L-threonyl-[protein] + ATP = O-phospho-L-threonyl-[protein] + ADP + H⁺

Molecule diagrams generated from .mol files obtained from the KEGG ftp site

reference

Proc Natl Acad Sci U S A 109:13608-13613 (2012)

PubMed id: 22869697

Identification of an N-terminal inhibitory extension as the primary mechanosensory regulator of twitchin kinase.

E.von Castelmur, J.Strümpfer, B.Franke, J.Bogomolovas, S.Barbieri, H.Qadota, P.V.Konarev, D.I.Svergun, S.Labeit, G.M.Benian, K.Schulten, O.Mayans.

ABSTRACT

No abstract given.