PDBsum entry 3utm

Transferase/signaling protein

PDB id: 3utm

Contents

Protein chains

320 a.a.

32 a.a.

Waters ×227

PDB id:

3utm

Name:

Transferase/signaling protein

Title:

Crystal structure of a mouse tankyrase-axin complex

Structure:

Tankyrase-1. Chain: a, b. Fragment: mtnks1 arc23 (unp residues 308-655). Synonym: tank1, trf1-interacting ankyrin-related adp-ribose polymerase 1, tankyrase i. Engineered: yes. Axin-1. Chain: c. Fragment: maxin1 n domain (unp residues 1-80).

Source:

Mus musculus. Mouse. Organism_taxid: 10090. Gene: tankryase1, tnks, tnks1. Expressed in: escherichia coli. Expression_system_taxid: 511693. Gene: axin, axin1, fu.

Resolution:

2.00Å R-factor: 0.209 R-free: 0.238

Authors:

Z.Cheng,S.Morrone,W.Xu

Key ref:

S.Morrone et al. (2012). Crystal structure of a Tankyrase-Axin complex and its implications for Axin turnover and Tankyrase substrate recruitment. Proc Natl Acad Sci U S A, 109, 1500-1505. PubMed id: 22307604

Date:

26-Nov-11 Release date: 18-Jan-12

Protein chains

Q6PFX9  (TNKS1_MOUSE) -  Poly [ADP-ribose] polymerase tankyrase-1 from Mus musculus

Seq: 1320 a.a.

Struc: 320 a.a.

Protein chain

O35625  (AXIN1_MOUSE) -  Axin-1 from Mus musculus

Seq: 863 a.a.

Struc: 32 a.a.

Enzyme reactions

• Enzyme class 1: Chains A, B: E.C.2.4.2.- - ?????
• Enzyme class 2: Chains A, B: E.C.2.4.2.30 - NAD(+) ADP-ribosyltransferase.

Pathway:

• Reaction: NAD⁺ + (ADP-D-ribosyl)n-acceptor = nicotinamide + (ADP-D- ribosyl)n+1-acceptor + H⁺

Note, where more than one E.C. class is given (as above), each may correspond to a different protein domain or, in the case of polyprotein precursors, to a different mature protein.

Molecule diagrams generated from .mol files obtained from the KEGG ftp site

Added reference

Proc Natl Acad Sci U S A 109:1500-1505 (2012)

PubMed id: 22307604

Crystal structure of a Tankyrase-Axin complex and its implications for Axin turnover and Tankyrase substrate recruitment.

S.Morrone, Z.Cheng, R.T.Moon, F.Cong, W.Xu.

ABSTRACT

No abstract given.