PDBsum entry 3uqf

Transferase/transferase inhibitor

PDB id: 3uqf

Contents

Protein chains

260 a.a.

Ligands

BK5 ×2

Waters ×69

PDB id:

3uqf

Name:

Transferase/transferase inhibitor

Title:

C-src kinase domain in complex with bki rm-1-89

Structure:

Proto-oncogene tyrosine-protein kinase src. Chain: a, b. Fragment: kinase domain (unp residues 251-533). Synonym: proto-oncogenE C-src, pp60c-src, p60-src. Engineered: yes

Source:

Gallus gallus. Bantam,chickens. Organism_taxid: 9031. Gene: src. Expressed in: escherichia coli. Expression_system_taxid: 562

Resolution:

2.27Å R-factor: 0.228 R-free: 0.256

Authors:

E.A.Merritt,E.T.Larson

Key ref:

E.T.Larson et al. (2012). Multiple determinants for selective inhibition of apicomplexan calcium-dependent protein kinase CDPK1. J Med Chem, 55, 2803-2810. PubMed id: 22369268

Date:

20-Nov-11 Release date: 14-Mar-12

Protein chains

P00523  (SRC_CHICK) -  Proto-oncogene tyrosine-protein kinase Src from Gallus gallus

Seq: 533 a.a.

Struc: 260 a.a.

Enzyme reactions

• Enzyme class: E.C.2.7.10.2 - non-specific protein-tyrosine kinase.
• Reaction: L-tyrosyl-[protein] + ATP = O-phospho-L-tyrosyl-[protein] + ADP + H⁺

Molecule diagrams generated from .mol files obtained from the KEGG ftp site

Added reference

J Med Chem 55:2803-2810 (2012)

PubMed id: 22369268

Multiple determinants for selective inhibition of apicomplexan calcium-dependent protein kinase CDPK1.

E.T.Larson, K.K.Ojo, R.C.Murphy, S.M.Johnson, Z.Zhang, J.E.Kim, D.J.Leibly, A.M.Fox, M.C.Reid, E.J.Dale, B.G.Perera, J.Kim, S.N.Hewitt, W.G.Hol, C.L.Verlinde, E.Fan, W.C.Van Voorhis, D.J.Maly, E.A.Merritt.

ABSTRACT

No abstract given.