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PDBsum entry 3uk6
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protein ligands Protein-protein interface(s) links
Hydrolase PDB id
3uk6

 

 

 

 

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Contents
Protein chains
298 a.a.
300 a.a.
321 a.a.
277 a.a.
294 a.a.
300 a.a.
283 a.a.
233 a.a.
Ligands
ADP ×12
PDB id:
3uk6
Name: Hydrolase
Title: Crystal structure of the tip48 (tip49b) hexamer
Structure: Ruvb-like 2. Chain: a, b, c, d, e, f, g, h, i, j, k, l. Fragment: unp residues 1-132, 239-463. Synonym: 48 kda tata box-binding protein-interacting protein, 48 kda tbp-interacting protein, 51 kda erythrocyte cytosolic protein, ecp- 51, ino80 complex subunit j, repressing pontin 52, reptin 52, tip49b, tip60-associated protein 54-beta, tap54-beta. Engineered: yes
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: cgi-46, ino80j, ruvbl2, tip48, tip49b. Expressed in: escherichia coli. Expression_system_taxid: 469008.
Resolution:
2.95Å     R-factor:   0.243     R-free:   0.264
Authors: M.Petukhov,A.Dagkessamanskaja,M.Bommer,T.Barrett,I.Tsaneva,A.Yakimov, R.Queval,A.Shvetsov,M.Khodorkovskiy,E.Kas,M.Grigoriev
Key ref: M.Petukhov et al. (2012). Large-scale conformational flexibility determines the properties of AAA+ TIP49 ATPases. Structure, 20, 1321-1331. PubMed id: 22748767
Date:
09-Nov-11     Release date:   25-Jul-12    
PROCHECK
Go to PROCHECK summary
 Headers
 References

Protein chain
Pfam   ArchSchema ?
Q9Y230  (RUVB2_HUMAN) -  RuvB-like 2 from Homo sapiens
Seq:
Struc: 		463 a.a.
298 a.a.
Protein chains
Pfam   ArchSchema ?
Q9Y230  (RUVB2_HUMAN) -  RuvB-like 2 from Homo sapiens
Seq:
Struc: 		463 a.a.
300 a.a.
Protein chains
Pfam   ArchSchema ?
Q9Y230  (RUVB2_HUMAN) -  RuvB-like 2 from Homo sapiens
Seq:
Struc: 		463 a.a.
321 a.a.
Protein chain
Pfam   ArchSchema ?
Q9Y230  (RUVB2_HUMAN) -  RuvB-like 2 from Homo sapiens
Seq:
Struc: 		463 a.a.
277 a.a.
Protein chain
Pfam   ArchSchema ?
Q9Y230  (RUVB2_HUMAN) -  RuvB-like 2 from Homo sapiens
Seq:
Struc: 		463 a.a.
294 a.a.
Protein chain
Pfam   ArchSchema ?
Q9Y230  (RUVB2_HUMAN) -  RuvB-like 2 from Homo sapiens
Seq:
Struc: 		463 a.a.
300 a.a.
Protein chain
Pfam   ArchSchema ?
Q9Y230  (RUVB2_HUMAN) -  RuvB-like 2 from Homo sapiens
Seq:
Struc: 		463 a.a.
283 a.a.
Protein chain
Pfam   ArchSchema ?
Q9Y230  (RUVB2_HUMAN) -  RuvB-like 2 from Homo sapiens
Seq:
Struc: 		463 a.a.
233 a.a.*
Key:    PfamA domain  Secondary structure  CATH domain
* PDB and UniProt seqs differ at 5 residue positions (black crosses)

 Enzyme reactions 
   Enzyme class: Chains A, B, C, D, E, F, G, H, I, J, K, L: E.C.3.6.4.12  - Dna helicase.
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]
      Reaction: ATP + H2O = ADP + phosphate + H+
ATP
 + H2O
 =
ADP
Bound ligand (Het Group name = ADP)
corresponds exactly 		+ phosphate
 + H(+)
Molecule diagrams generated from .mol files obtained from the KEGG ftp site

 

 
    reference    
 
 
Structure 20:1321-1331 (2012)
PubMed id: 22748767  
 
 
Large-scale conformational flexibility determines the properties of AAA+ TIP49 ATPases.
M.Petukhov, A.Dagkessamanskaja, M.Bommer, T.Barrett, I.Tsaneva, A.Yakimov, R.Quéval, A.Shvetsov, M.Khodorkovskiy, E.Käs, M.Grigoriev.
 
  ABSTRACT  
 
No abstract given.

 

 

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