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UniProt functional annotation for Q90WA1 | ||
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| UniProt code: Q90WA1. |
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| Organism: | |
Pseudonaja textilis textilis (Eastern brown snake). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera; Serpentes; Colubroidea; Elapidae; Acanthophiinae; Pseudonaja. |
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| Function: | |
Strongly inhibits plasmin (Ki=0.44 nM) and trypsin (Ki=0.42 nM). Has little effect on plasma (Ki=1870 nM) and tissue (Ki=12900 nM) kallikreins. In vivo, reduces bleeding in a small animal model. {ECO:0000269|PubMed:10847427, ECO:0000269|PubMed:12406072, ECO:0000269|PubMed:16707925, ECO:0000269|PubMed:19236611, ECO:0000269|PubMed:21843588, ECO:0000269|PubMed:23335990}. |
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| Subcellular location: | |
Secreted. |
| Tissue specificity: | |
Expressed by the venom gland. |
| Mass spectrometry: | |
Mass=6689.3; Method=MALDI; Evidence={ECO:0000269|PubMed:10847427}; |
| Pharmaceutical: | |
Is under preclinical trial by the Australian biopharmaceutical company QRxPharma Ltd, its subsidiary Venomics Pty Ltd (VPL) and the University of Queensland (UQ) under the name textilinin-1 (Q8008). Tested as a potent and selective plasmin inhibitor that has application as an anti-fibrinolytic agent to reduce blood loss associated with complex surgeries. It is being investigated as an alternative treatment to aprotinin (Trasylol). |
| Miscellaneous: | |
Has no effect on tissue plasminogen inhibitor (tPA/PLAT), urokinase, activated protein C (APC), elastase, factor Xa, alpha-factor XIIa, thrombin, and factor VIIa. {ECO:0000305|PubMed:21843588}. |
| Similarity: | |
Belongs to the venom Kunitz-type family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.