spacer
spacer

PDBsum entry 3uin

Go to PDB code: 
protein Protein-protein interface(s) links
Ligase/isomerase/protein binding PDB id
3uin

 

 

 

 

Loading ...

 
JSmol PyMol  
Contents
Protein chains
157 a.a.
78 a.a.
156 a.a.
65 a.a.
Waters ×42
PDB id:
3uin
Name: Ligase/isomerase/protein binding
Title: Complex between human rangap1-sumo2, ubc9 and the ir1 domain from ranbp2
Structure: Sumo-conjugating enzyme ubc9. Chain: a. Synonym: sumo-protein ligase, ubiquitin carrier protein 9, ubiquitin carrier protein i, ubiquitin-conjugating enzyme e2 i, ubiquitin- protein ligase i, p18. Engineered: yes. Small ubiquitin-related modifier 2. Chain: b. Fragment: unp residues 14-93.
Source: Homo sapiens. Human. Organism_taxid: 9606. Gene: ubc9, ubce9, ube2i. Expressed in: escherichia coli. Expression_system_taxid: 469008. Gene: smt3a, smt3h2, sumo2. Gene: kiaa1835, rangap1, sd. Gene: nup358, ranbp2.
Resolution:
2.60Å     R-factor:   0.214     R-free:   0.264
Authors: J.R.Gareau,D.Reverter,C.D.Lima
Key ref: J.R.Gareau et al. (2012). Determinants of small ubiquitin-like modifier 1 (SUMO1) protein specificity, E3 ligase, and SUMO-RanGAP1 binding activities of nucleoporin RanBP2. J Biol Chem, 287, 4740-4751. PubMed id: 22194619
Date:
05-Nov-11     Release date:   28-Dec-11    
PROCHECK
Go to PROCHECK summary
 Headers
 References

Protein chain
Pfam   ArchSchema ?
P63279  (UBC9_HUMAN) -  SUMO-conjugating enzyme UBC9 from Homo sapiens
Seq:
Struc:
158 a.a.
157 a.a.
Protein chain
Pfam   ArchSchema ?
P61956  (SUMO2_HUMAN) -  Small ubiquitin-related modifier 2 from Homo sapiens
Seq:
Struc:
95 a.a.
78 a.a.
Protein chain
Pfam   ArchSchema ?
P46060  (RAGP1_HUMAN) -  Ran GTPase-activating protein 1 from Homo sapiens
Seq:
Struc:
 
Seq:
Struc:
587 a.a.
156 a.a.
Protein chain
Pfam   ArchSchema ?
P49792  (RBP2_HUMAN) -  E3 SUMO-protein ligase RanBP2 from Homo sapiens
Seq:
Struc:
 
Seq:
Struc:
 
Seq:
Struc:
 
Seq:
Struc:
 
Seq:
Struc:
 
Seq:
Struc:
 
Seq:
Struc:
3224 a.a.
65 a.a.
Key:    PfamA domain  Secondary structure  CATH domain

 Enzyme reactions 
   Enzyme class: Chains A, D: E.C.2.3.2.-  - ?????
[IntEnz]   [ExPASy]   [KEGG]   [BRENDA]

 

 
J Biol Chem 287:4740-4751 (2012)
PubMed id: 22194619  
 
 
Determinants of small ubiquitin-like modifier 1 (SUMO1) protein specificity, E3 ligase, and SUMO-RanGAP1 binding activities of nucleoporin RanBP2.
J.R.Gareau, D.Reverter, C.D.Lima.
 
  ABSTRACT  
 
No abstract given.

 

Literature references that cite this PDB file's key reference

  PubMed id Reference
22842904 A.Plechanovová, E.G.Jaffray, M.H.Tatham, J.H.Naismith, and R.T.Hay (2012).
Structure of a RING E3 ligase and ubiquitin-loaded E2 primed for catalysis.
  Nature, 489, 115-120.
PDB code: 4ap4
The most recent references are shown first. Citation data come partly from CiteXplore and partly from an automated harvesting procedure. Note that this is likely to be only a partial list as not all journals are covered by either method. However, we are continually building up the citation data so more and more references will be included with time. Where a reference describes a PDB structure, the PDB code is shown on the right.

 

spacer

spacer