UniProt functional annotation for Q9Y237

UniProt code: Q9Y237.

Organism: Homo sapiens (Human).
Taxonomy: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.
 
Function: Isoform 1 is involved as a ribosomal RNA processing factor in ribosome biogenesis. Binds to tightly bent AT-rich stretches of double-stranded DNA. {ECO:0000269|PubMed:19369196}.
 
Function: Isoform 2 binds to double-stranded DNA. {ECO:0000269|PubMed:19369196}.
 
Catalytic activity: Peptidylproline (omega=180) = peptidylproline (omega=0).
Subunit: Isoform 1 is found in pre-ribosomal ribonucleoprotein (pre-rRNP) complexes. {ECO:0000250}.
Subcellular location: Isoform 1: Nucleus, nucleolus. Cytoplasm, cytoskeleton, spindle. Cytoplasm. Note=Colocalizes in the nucleolus during interphase and on the spindle apparatus during mitosis with NPM1.
Subcellular location: Isoform 2: Mitochondrion. Mitochondrion matrix. Note=Imported in a time- and membrane potential-dependent manner to the mitochondrial matrix, but without concomitant processing of the protein. Directed to mitochondria by a novel N- terminal domain that functions as non-cleavable mitochondrial targeting peptide.
Tissue specificity: Isoform 2 is much more stable than isoform 1 (at protein level). Ubiquitous. Isoform 1 and isoform 2 are expressed in kidney, liver, blood vessel, brain, mammary gland, skeletal muscle, small intestine and submandibularis. Isoform 1 transcripts are much more abundant than isoform 2 in each tissue analyzed. {ECO:0000269|PubMed:10100858, ECO:0000269|PubMed:10364457, ECO:0000269|PubMed:16522211}.
Domain: The PPIase domain enhances mitochondrial targeting.
Ptm: Phosphorylated. Isoform 1 phosphorylation occurs both in the nucleus and the cytoplasm. Isoform 1 phosphorylation at Ser-19 does not affect its PPIase activity but is required for nuclear localization, and the dephosphorylation is a prerequisite for the binding to DNA. The unphosphorylated isoform 1 associates with the pre-rRNP complexes in the nucleus. {ECO:0000269|PubMed:12860119, ECO:0000269|PubMed:19369196}.
Ptm: Isoform 2 is sumoylated with SUMO2 and SUMO3. {ECO:0000269|PubMed:16522211}.
Similarity: Belongs to the PpiC/parvulin rotamase family. PIN4 subfamily. {ECO:0000305}.
Similarity: Contains 1 PpiC domain. {ECO:0000255|PROSITE- ProRule:PRU00278}.
Sequence caution: Sequence=AAH05234.2; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH70288.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAI04654.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAI11395.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAG54532.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

Annotations taken from UniProtKB at the EBI.