UniProt functional annotation for P37107



	UniProt functional annotation for P37107

UniProt code: P37107.

Organism: Arabidopsis thaliana (Mouse-ear cress).

Taxonomy: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.

Function: Involved in cotranslational and post-translational sorting of thylakoid proteins. Binds GTP specifically. Activates the GTPase activity of CPFTSY when bound together. Required for light-harvesting chlorophyll a/b-binding protein (LHCP) integration into thylakoids. {ECO:0000269|PubMed:10480939, ECO:0000269|PubMed:11356852, ECO:0000269|PubMed:17475780, ECO:0000269|PubMed:18633119}.

Subunit: Component of the cpSRP complex, composed of a FFC/cpSRP54 monomer and a CAO/cpSRP43 dimer. Interacts (via C-terminus) with CAO/cpSRP43 and with CPFTSY. Interacts with the third transmembrane domain of LHCP. Interacts with the PSBA/D1 nascent chain, but only when it is attached to the 70S ribosome and if it is shorter than 189 amino acid residues. {ECO:0000269|PubMed:10480939, ECO:0000269|PubMed:11356852, ECO:0000269|PubMed:15632183, ECO:0000269|PubMed:17475780, ECO:0000269|PubMed:19587121, ECO:0000269|PubMed:9927433}.

Subcellular location: Plastid, chloroplast stroma.

Tissue specificity: Most abundant in green shoot tissue and lower levels seen in the roots and etiolated buds. {ECO:0000269|PubMed:16813577}.

Domain: The M-domain stimulates the interaction between CPFTSY and the chloroplast signal recognition particle (cpSRP).

Domain: The C-terminal residues (539-564) are required for interaction with CAO/cpSRP43.

Disruption phenotype: Pale green with delayed development. {ECO:0000269|PubMed:18633119}.

Miscellaneous: Unlike eukaryotic or prokaryotic signal recognition particle (SRP), the chloroplast SRP from higher plants lacks an SRP-RNA component. It targets both chloroplast-encoded and nucleus-encoded substrates to the thylakoid membrane, post-translationally for the nucleus-encoded proteins and co-translationally for the chloroplast- encoded proteins.

Similarity: Belongs to the GTP-binding SRP family. SRP54 subfamily. {ECO:0000305}.

Annotations taken from UniProtKB at the EBI.


Organism:		Arabidopsis thaliana (Mouse-ear cress).
Taxonomy:		Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.



Function:		Involved in cotranslational and post-translational sorting of thylakoid proteins. Binds GTP specifically. Activates the GTPase activity of CPFTSY when bound together. Required for light-harvesting chlorophyll a/b-binding protein (LHCP) integration into thylakoids. {ECO:0000269\|PubMed:10480939, ECO:0000269\|PubMed:11356852, ECO:0000269\|PubMed:17475780, ECO:0000269\|PubMed:18633119}.


Subunit:		Component of the cpSRP complex, composed of a FFC/cpSRP54 monomer and a CAO/cpSRP43 dimer. Interacts (via C-terminus) with CAO/cpSRP43 and with CPFTSY. Interacts with the third transmembrane domain of LHCP. Interacts with the PSBA/D1 nascent chain, but only when it is attached to the 70S ribosome and if it is shorter than 189 amino acid residues. {ECO:0000269\|PubMed:10480939, ECO:0000269\|PubMed:11356852, ECO:0000269\|PubMed:15632183, ECO:0000269\|PubMed:17475780, ECO:0000269\|PubMed:19587121, ECO:0000269\|PubMed:9927433}.
Subcellular location:		Plastid, chloroplast stroma.
Tissue specificity:		Most abundant in green shoot tissue and lower levels seen in the roots and etiolated buds. {ECO:0000269\|PubMed:16813577}.
Domain:		The M-domain stimulates the interaction between CPFTSY and the chloroplast signal recognition particle (cpSRP).
Domain:		The C-terminal residues (539-564) are required for interaction with CAO/cpSRP43.
Disruption phenotype:		Pale green with delayed development. {ECO:0000269\|PubMed:18633119}.
Miscellaneous:		Unlike eukaryotic or prokaryotic signal recognition particle (SRP), the chloroplast SRP from higher plants lacks an SRP-RNA component. It targets both chloroplast-encoded and nucleus-encoded substrates to the thylakoid membrane, post-translationally for the nucleus-encoded proteins and co-translationally for the chloroplast- encoded proteins.
Similarity:		Belongs to the GTP-binding SRP family. SRP54 subfamily. {ECO:0000305}.